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Notum Antibodies

AND Notum ELISA kits, Notum Proteins

Many biological assays use antibodies to detect Notum, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Notum in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Notum antibodies...

We validate the specificity of these antibodies to Notum by testing them on tissues known to express Notum positively and negatively. Browse below to find the Notum antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Notum Infographic by Boster Bio

Notum protein infographic

All Notum Products

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Product

Figures

Specificity

Applications

Price

Anti-NOTUM Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A03235
0.1 mg

NOTUM (NM_178493) Human Over-expression Lysate

Human

$628
Cat # LS147111
100 µg

Notum Overview

Facts about Palmitoleoyl-protein carboxylesterase NOTUM.

Palmitoleoyl-protein carboxylesterase NOTUM (Notum)

Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by especially mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.

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Gene Information

Mouse
Gene Name:	Notum
Uniprot:	Q8R116
Entrez:	77583

Gene Information

Family

Belongs to:

pectinacetylesterase family

Family

Alternative Names

EC 3.-; notum pectinacetylesterase homolog (Drosophila); Notum; protein notum homolog

Molecular Weight

Mass (kDA):
56.584 kDA

Molecular Weight

Genomic Context


Mouse

Location:	11\|11 E2
Sequence:	11;

Tissue Specificity

Widely expressed. Expressed in lung, ovary, kidney, liver and brain. Not detected in thymus, heart, spleen, stomach, skeletal muscle and bone marrow.

Diseases

Nervousness
Embryonic Mosaic
Neoplasms
Tissue Adhesions
Muscular Fasciculation
Malignant Neoplasms
Congenital Abnormality
Stenosis
Cell Transformation, Neoplastic
Sclerosis
Prion Diseases
Neoplasm Metastasis
Primary Lateral Sclerosis

Dementia
Amyotrophic Lateral Sclerosis
Carcinoma
Macular Corneal Dystrophy Type I
Chimera Disorder
Neurofibrillary Tangles
Cold Intolerance

Disease

Pathways

Lateral Inhibition
Larval Development
Neurogenesis
Wing Disc Development
Cell Fate Specification
Localization
Cell Division
Segmentation
Notch Signaling Pathway
Regeneration
Cell Adhesion
Cell Proliferation
Organ Development

Delamination
Pathogenesis
Flight
Endocytosis
Eye Development
Notum Development
Imaginal Disc Development

Pathways

PTMs

Cleavage
Gpi Anchoring

Phosphorylation
Ubiquitination

Bosterbio | ELISA Kits, Antibodies, Antibody Company

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Notum

References

PMID: 17967162 by Traister A., et al. Mammalian Notum induces the release of glypicans and other GPI- anchored proteins from the cell surface.

PMID: 25771893 by Zhang X., et al. Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation.