Junctophilin-1 Antibodies

AND JPH1 ELISA kits, Junctophilin-1 Proteins

Many biological assays use antibodies to detect Junctophilin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Junctophilin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Junctophilin-1 antibodies...

We validate the specificity of these antibodies to Junctophilin-1 by testing them on tissues known to express JPH1 positively and negatively. Browse below to find the JPH1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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JPH1 Infographic by Boster Bio

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Anti-Junctophilin-1 JPH1 Antibody

Human, Mouse, Rat

ELISA, IHC-P, WB

$449
Cat # A08565
0.1 mg

JPH1 Overview

Facts about Junctophilin-1.

JPH1 3D structure. Source: alphafold

Junctophilin-1 (JPH1)

Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which connect the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural base for functional cross-talk between the cell surface and intracellular calcium release channels.

JPH1 contributes to the building of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. .

Gene Information

Human
Gene Name:	JPH1
Uniprot:	Q9HDC5
Entrez:	56704

Family

Belongs to:

junctophilin family

Alternative Names

DKFZp762L0313; JP-1junctophilin type1; JP1junctophilin-1; junctophilin 1; Junctophilin type 1; mitsugumin72

Molecular Weight

Mass (kDA):
71.686 kDA

Genomic Context


Human

Location:	8q21.11
Sequence:	8; NC_000008.11 (74234700..74321540, complement)

Tissue Specificity

Abundantly expressed in skeletal muscle. Very low levels in heart.

Subcellular Localizations

Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands (By similarity).

Diseases

Hypertrophic Cardiomyopathy
Heart Diseases
Cardiomyopathies
Hypertrophy
Cardiac Arrest

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JPH1

References

PMID: 10891348 by Nishi M., et al. Characterization of human junctophilin subtype genes.