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Ran-binding protein 9 Antibodies
AND RANBP9 ELISA kits, Ran-binding protein 9 Proteins
Many biological assays use antibodies to detect Ran-binding protein 9, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ran-binding protein 9 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ran-binding protein 9 antibodies...
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RANBP9 Infographic by Boster Bio
All RANBP9 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A03448-1
100 µg/vial
Cat # A03448-1
100 µg/vial
RANBP9 Overview
Facts about Ran-binding protein 9.
Ran-binding protein 9 (RANBP9)
May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924).
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA- 1 and other integrins (PubMed:14722085).
Gene Information
| Human | |
|---|---|
| Gene Name: | RANBP9 |
| Uniprot: | Q96S59 |
| Entrez: | 10048 |
Family
| Belongs to: |
|---|
| RANBP9/10 family |
Alternative Names
BPM90; BPM-L; RAN binding protein 9; Ran Binding Protein in the Microtubule organizing center; ran binding protein, centrosomal; ran-binding protein 9; Ran-binding protein M; RanBP7; RanBP9; RanBPM; RANBPMnovel centrosomal protein RanBPM
Molecular Weight
Mass (kDA):
77.847 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p23 |
| Sequence: | 6; NC_000006.12 (13621498..13711835, complement) |
Tissue Specificity
Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest levels in lung. Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular layer of cerebellum and the Purkinje cells.
Subcellular Localizations
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. The unphosphorylated form is predominantly cytoplasmic. A phosphorylated form is associated with the plasma membrane.
Diseases
- Alzheimer's Disease
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Ataxia
- Glioma
- Neoplasm Invasiveness
- Carcinoma
- Telomere Shortening
- Nervousness
- Renal Cell Carcinoma
- Memory Impairment
Interacting Proteins
- DISC1
- DYRK1B
- ENTPD1
- Grm2
- OPRM1
- S100A7
Pathways
- Localization
- Endocytosis
- Cell Growth
- Cell Adhesion
- Cell Cycle
- Pathogenesis
- Mitosis
- Spermatogenesis
- Cytokinesis
- Senescence
- Translation
- Cell Death
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RANBP9
bosterbio.com/bosterbio-gene-info-cards/RANBP9
References
PMID: 11470507 by Nishitani H., et al. Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex.
PMID: 9817760 by Nakamura M., et al. When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin.