Junctophilin-3 Antibodies

AND JPH3 ELISA kits, Junctophilin-3 Proteins

Many biological assays use antibodies to detect Junctophilin-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Junctophilin-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Junctophilin-3 antibodies...

We validate the specificity of these antibodies to Junctophilin-3 by testing them on tissues known to express JPH3 positively and negatively. Browse below to find the JPH3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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JPH3 Infographic by Boster Bio

All JPH3 Products

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Product

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Specificity

Applications

Price

Anti-Junctophilin-3 JPH3 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A08160
0.1 mg

JPH3 (NM_020655) Human Over-expression Lysate

Human

$628
Cat # LS057338
100 µg

JPH3 Overview

Facts about Junctophilin-3.

JPH3 3D structure. Source: alphafold

Junctophilin-3 (JPH3)

Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which connect the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural base for operational cross-talk between the cell surface and intracellular calcium release channels.

JPH3 is brain- specific and appears to have an active part in some specific neurons involved in motor coordination and memory. .

Gene Information

Human
Gene Name:	JPH3
Uniprot:	Q8WXH2
Entrez:	57338

Family

Belongs to:

junctophilin family

Alternative Names

CAGL237; junctophilin 3; junctophilin type 3

Molecular Weight

Mass (kDA):
81.469 kDA

Genomic Context


Human

Location:	16q24.2
Sequence:	16; NC_000016.10 (87601835..87698156)

Tissue Specificity

Specifically expressed in brain.

Subcellular Localizations

Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity).

Diseases

Huntington Disease
Trinucleotide Repeat Expansion
Neurodegenerative Disorders
Dementia
Chorea
Atrophy
Impaired Cognition
Chorea Acanthocytosis Syndrome
Ataxia
Secondary Parkinson Disease
Pallidoluysian Degeneration
Dyskinetic Syndrome

Myoclonus
Dentatorubral-pallidoluysian Atrophy
Dystonia Disorders
Blood Group Deletion Syndrome
Ataxia, Spinocerebellar
Movement Disorders

Pathways

Pathogenesis
Cell Death
Localization
Homeostatic Process
Glomerular Filtration

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JPH3

References

PMID: 10891348 by Nishi M., et al. Characterization of human junctophilin subtype genes.

PMID: 11694876 by Holmes S.E., et al. A repeat expansion in the gene encoding junctophilin-3 is associated with Huntington disease-like 2.