This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Glycine amidinotransferase, mitochondrial.
May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.
Human | |
---|---|
Gene Name: | GATM |
Uniprot: | P50440 |
Entrez: | 2628 |
Belongs to: |
---|
amidinotransferase family |
AGATtransamidinase; AT; EC 2.1.4; EC 2.1.4.1; glycine amidinotransferase (L-arginine:glycine amidinotransferase); glycine amidinotransferase, mitochondrial; L-arginine:glycine amidinotransferase; Transamidinase
Mass (kDA):
48.455 kDA
Human | |
---|---|
Location: | 15q21.1 |
Sequence: | 15; NC_000015.10 (45361124..45402227, complement) |
Expressed in brain, heart, kidney, liver, lung, salivary gland and skeletal muscle tissue, with the highest expression in kidney. Biallelically expressed in placenta and fetal tissues.
[Isoform 1]: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Probably attached to the outer side of the inner membrane.; [Isoform 2]: Cytoplasm.
PMID: 8313955 by Humm A., et al. The amino acid sequences of human and pig L-arginine:glycine amidinotransferase.
PMID: 3800397 by Gross M.D., et al. The purification and characterization of human kidney L- arginine:glycine amidinotransferase.