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- Table of Contents
Facts about Lysosomal acid glucosylceramidase.
Human | |
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Gene Name: | GBA |
Uniprot: | P04062 |
Entrez: | 2629 |
Belongs to: |
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glycosyl hydrolase 30 family |
Acid beta-glucosidase; Alglucerase; beta-glucocerebrosidase; D-glucosyl-N-acylsphingosine glucohydrolase; EC 3.2.1.45; GBA; GBA1; GC; GCB; GLUC; glucosidase, beta, acid; glucosidase, beta; acid (includes glucosylceramidase); Glucosylceramidase; Imiglucerase; lysosomal glucocerebrosidase
Mass (kDA):
59.716 kDA
Human | |
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Location: | 1q22 |
Sequence: | 1; NC_000001.11 (155234452..155244627, complement) |
Lysosome membrane; Peripheral membrane protein; Lumenal side. Interaction with saposin-C promotes membrane association (PubMed:10781797). Targeting to lysosomes occurs through an alternative MPR-independent mechanism via SCARB2 (PubMed:18022370).
PMID: 3864160 by Sorge J., et al. Molecular cloning and nucleotide sequence of human glucocerebrosidase cDNA.
PMID: 3001061 by Tsuji S., et al. Nucleotide sequence of cDNA containing the complete coding sequence for human lysosomal glucocerebrosidase.