Zinc finger protein Gfi-1 Antibodies

Zinc finger protein Gfi-1 (GFI1)

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Gene Information

Human
Gene Name:	GFI1
Uniprot:	Q99684
Entrez:	2672

Family

Belongs to:
No superfamily

Alternative Names

GFI1; GFI-1; growth factor independence-1; growth factor independent 1 transcription repressor; growth factor independent 1; Growth factor independent protein 1; Pal-1; SCN2; Zinc finger protein 163; zinc finger protein Gfi-1; ZNF163; ZNF163FLJ94509

Molecular Weight

Mass (kDA):
45.297 kDA

Genomic Context

Human
Location:	1p22.1
Sequence:	1; NC_000001.11 (92473043..92486925, complement)

Subcellular Localizations

Nucleus. Colocalizes with PIAS3 and RUNX1T1 in nuclear dots.

Diseases

• Leukemia
• Lymphoma
• Neoplasms
• Severe Congenital Neutropenia
• Malignant Neoplasms
• Leukemogenesis
• Cell Transformation, Neoplastic
• Myeloid Leukemia
• Leukemia, Myelocytic, Acute
• T-cell Lymphoma
• Infective Disorder
• Immunologic Deficiency Syndromes
• Bacterial Infections

• Myeloid Leukemia, Chronic
• Complete Hearing Loss
• Autoimmunity
• Retroviridae Infections
• Neuroblastoma
• Tissue Adhesions
• Acute Lymphocytic Leukemia

Interacting Proteins

• Ajuba
• CHAF1A
• EHMT2
• HDAC1
• PRDM5

• RELA
• Spi1

Pathways

• Cell Differentiation
• Cell Development
• Cell Proliferation
• Cell Cycle
• Ear Development
• Pathogenesis
• Immune Response
• Inner Ear Development
• Cytokine Production
• Oncogenesis
• Neutrophil Differentiation
• Localization
• Methylation

• Cell Death
• Hair Cell Differentiation
• Cell Activation
• T Cell Activation
• Regeneration
• Inflammatory Response
• Innate Immune Response

PTMs

• Methylation
• Phosphorylation
• Acetylation

• Demethylation
• Deacetylation
• Ubiquitination

Research Areas

• Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GFI1

The Best Uses Of The GFI1 Marker

This article will provide you with the background information on Steven Boster, His research and clinical work as well as the best uses of the GFI1 marker. It will also explain His work and how it has helped scientists discover new treatments for numerous types of diseases. Find out more about this pioneer in gene therapy. This bio will give you more details about the background of the GFI1 marker, as well as the most recent advances, and how to use it effectively.

The story of Steven Boster

Steve Boster was born in Joliet (IL) on June 6 July 1947. He worked in sales for retail for many years , and also served in the U.S. Army. Steve's legacy includes his wife, Nina Mae, two children, 6 grandchildren, as well as 4 sisters and brothers. His siblings Kimberly Boster and Jack and David Boster are his surviving family members, as well as his nieces, nephews and nephews.

In addition to his work in the field of chemistry, Steve loved the music of the southern gospel and sang so low that people in the audience would be astonished. He was a huge lover of sports and always rooted against the opposing side. He was also a major fan of auto racing and was never a miss for an event at the local dirt track on Friday nights. He also attended other races on weekends. He loved to cheer on his friends, regardless of their age.

His research

In the past researchers have focused on different factors that could contribute to the development of disease-specific therapies including the use of specific gene fusions and stem cell transplants. GFI1 is a major factor in controlling the cell cycle. However, it has been overlooked. This protein is a marker for Ets2 the gene that is highly enriched in Jurkat cell lines. This gene regulates monocyte differentiation and myeloblasts.

The study found that Gfi-1 binding and expression is reduced in the HL-60 cell line during maturation which is a precursor to granulocytes. The reduced Gfi-1 activity could explain the slight divergence between Gfi1 and GFP levels of mRNA expression. Thus, the Gfi1 marker isn't believed to play a crucial part in determining the TCR pre-TCR range.

His research work

Dr. Tarik Moroy's clinical work with the GFI1 marker has helped to determine the connection between a variant form the GFI1 gene and the development of acute myeloid leukemia (AML). The study included more than 1,600 patients from the Netherlands, Germany and the United States. The study was conducted in collaboration with other research institutes across Europe and the United States. Dr. Moroy and his collaborators have reported that GFI136N is a new marker that helps to determine the susceptibility of a person's genetics.

His current research

GFI1 is a key marker for the production of precursors to hematopoietic cells. In the end, hematopoietic progenitors are produced by hemomatogenic epithelium. The GFI1 gene is needed for this process. Thus, understanding its function is crucial to the differentiation of the endothelial cells.

The Gfi-1 gene is an activator of transcription as well as also a regulator. Both kinds of action are determined by the promoter and the development context of the gene. It is believed that GFI-1 regulates the cell cycle, but the mechanism isn't fully understood. His current research using the GFI1 marker could provide new insights into gene control. This marker could ultimately have a broad range of applications, ranging from the identification of cancerous tumors, to determining the best chemotherapy for the patient.

The zebrafish GFI1 genes are located on chromosome 6. They are extremely identical to their mammalian cousins. The zebrafish GFI1 gene regulates transcription and also recruits other transcription factors. This coordinates genes that determine terminal differentiation. The GFI1 gene can be expressed in a variety cell types, including macrophages and T lymphocytes. The zebrafish GFI1 gene is highly expressed in Jurkat cells.