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- Table of Contents
Facts about Glutathione hydrolase 1 proenzyme.
In the presence of high concentrations of dipeptides and a few amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine source and contributes to maintain intracellular GSH level.
Human | |
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Gene Name: | GGT1 |
Uniprot: | P19440 |
Entrez: | 2678 |
Belongs to: |
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gamma-glutamyltransferase family |
CD224 antigen; CD224; D22S672; D22S732; EC 2.3.2.2; gamma-glutamyl transpeptidase; gamma-glutamyltransferase 1MGC96904; gamma-glutamyltranspeptidase 1; GGT 1; GGTMGC96963; glutamyl transpeptidase; GTG; MGC96892
Mass (kDA):
61.41 kDA
Human | |
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Location: | 22q11.23 |
Sequence: | 22; NC_000022.11 (24583750..24629005) |
Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. Isoform 3 is lung-specific. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein.
Cell membrane; Single-pass type II membrane protein.
PMID: 2904146 by Rajpert-De Meyts E., et al. Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase.
PMID: 2907498 by Sakamuro D., et al. The primary structure of human gamma-glutamyl transpeptidase.