GABRB2 Antibodies

AND GABRB2 ELISA kits, GABRB2 Proteins

Many biological assays use antibodies to detect GABRB2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GABRB2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GABRB2 antibodies...

We validate the specificity of these antibodies to GABRB2 by testing them on tissues known to express GABRB2 positively and negatively. Browse below to find the GABRB2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GABRB2 Infographic by Boster Bio

All GABRB2 Products

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Product

Figures

Specificity

Applications

Price

Anti-GABAA R Beta 2 (R431) GABRB2 Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A04049
100ul

Anti-GABA A Receptor beta 2 Rabbit Monoclonal Antibody

Human, Mouse, Rat

$370
Cat # M04049
100 μl/vial

GABA A Receptor beta 2 (GABRB2) (NM_021911) Human Over-expression Lysate

Human

$960
Cat # LS002561
100 µg

GABRB2 Overview

Facts about Gamma-aminobutyric acid receptor subunit beta-2.

GABRB2 3D structure. Source: alphafold

Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2)

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine.

Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel.

Gene Information

Human
Gene Name:	GABRB2
Uniprot:	P47870
Entrez:	2561

Family

Belongs to:

ligand-gated ion channel (TC 1.A.9) family

Alternative Names

GABA A R beta 2; GABA(A) receptor subunit beta-2; GABAAR beta 2; GABAARb2; GABRB2; gamma-aminobutyric acid (GABA) A receptor, beta 2; gamma-aminobutyric acid A receptor beta 2; gamma-aminobutyric acid receptor subunit beta-2; MGC119386; MGC119388; MGC119389

Molecular Weight

Mass (kDA):
59.15 kDA

Genomic Context


Human

Location:	5q34
Sequence:	5; NC_000005.10 (161288429..161548404, complement)

Tissue Specificity

Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.

Subcellular Localizations

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.

Diseases

Schizophrenia
Dysequilibrium Syndrome
Nervousness
Epilepsy
Psychotic Disorders
Bipolar Disorder
Febrile Convulsions
Mental Disorders
Borderline Personality Disorder
Cholangiocarcinoma
Malnutrition
Personality Disorders

Ataxia
Epilepsy, Generalized
Antisocial Personality Disorder
5,10-methylenetetrahydrofolate Reductase Deficiency
Anxiety Disorders
Epilepsies, Myoclonic

Pathways

Pathogenesis
Localization
Righting Reflex
Synaptic Transmission
Reflex
Methylation
Response To Anesthetic
Dna Hypomethylation
Response To Hypoxia
Glycosylation
Dna Methylation
Neurogenesis
Endocytosis

Ion Homeostasis
Response To Ethanol
Drug Resistance
Membrane Depolarization
Translation
Receptor Internalization
Cognition

PTMs

Phosphorylation

Cleavage

Methylation

Research Areas

Neuronal Cell Markers
Neuroscience
Neurotransmission

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GABRB2

References

PMID: 8264558 by Hadingham K.L., et al. Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors.

PMID: 7707873 by McKinley D.D., et al. Cloning, sequence analysis and expression of two forms of mRNA coding for the human beta 2 subunit of the GABAA receptor.