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- Table of Contents
Facts about Tyrosine-protein kinase Fer.
Acts downstream of EGFR to promote regeneration of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle.
Human | |
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Gene Name: | FER |
Uniprot: | P16591 |
Entrez: | 2241 |
Belongs to: |
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protein kinase superfamily |
EC 2.7.10; EC 2.7.10.2; fer (fps/fes related) tyrosine kinase; Fer; p94-Fer; Phosphoprotein NCP94; Proto-oncogene c-Fer; TYK3; TYK3phosphoprotein NCP94; Tyrosine kinase 3; tyrosine-protein kinase Fer
Mass (kDA):
94.638 kDA
Human | |
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Location: | 5q21.3 |
Sequence: | 5; NC_000005.10 (108746085..109196841) |
Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed.
Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts.
PMID: 2725517 by Hao Q.-L., et al. Isolation and sequence analysis of a novel human tyrosine kinase gene.
PMID: 22223638 by Makovski A., et al. Intronic promoter drives the BORIS-regulated expression of FerT in colon carcinoma cells.