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- Table of Contents
Facts about FYVE, RhoGEF and PH domain-containing protein 1.
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP.
Plays a role in regulating the actin cytoskeleton and cell shape..
Human | |
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Gene Name: | FGD1 |
Uniprot: | P98174 |
Entrez: | 2245 |
Belongs to: |
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No superfamily |
faciogenital dysplasia (Aarskog-ScRhoGEF and PH domain-containing protein 1; Faciogenital dysplasia 1 protein; FGDYMRXS16; FYVE, RhoGEF and PH domain containing 1; Rho/Rac guanine nucleotide exchange factor FGD1; ZFYVE3AAS; Zinc finger FYVE domain-containing protein 3
Mass (kDA):
106.561 kDA
Human | |
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Location: | Xp11.22 |
Sequence: | X; NC_000023.11 (54445454..54496234, complement) |
Expressed in fetal heart, brain, lung, kidney and placenta. Less expressed in liver; adult heart, brain, lung, pancreas and skeletal muscle.
Cytoplasm. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Associated with membrane ruffles and lamellipodia.
PMID: 7954831 by Pasteris N.G., et al. Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: a putative Rho/Rac guanine nucleotide exchange factor.
PMID: 8969170 by Zheng Y., et al. The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs- specific guanine-nucleotide exchange factor.