Forkhead box protein N4 (Foxn4)

Transcription factor essential for neurological and some non- neural tissues development, such as lung and retina respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'.

During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternate photoreceptor cell fates through triggering DLL4- NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates through spinal cord neurogenesis.