This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Forkhead box protein N4.
During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternate photoreceptor cell fates through triggering DLL4- NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates through spinal cord neurogenesis.
Mouse | |
---|---|
Gene Name: | Foxn4 |
Uniprot: | Q8K3Q3 |
Entrez: | 116810 |
Belongs to: |
---|
No superfamily |
Forkhead box protein N4
Mass (kDA):
56.121 kDA
Mouse | |
---|---|
Location: | 5|5 F |
Sequence: | 5; |
Mainly expressed in proliferator progenitor cells in brain and retina rather than differentiated cells. In contrast, is expressed only in postmitotic epithelial cells rather than in proliferative progenitors in the proximal airway.
PMID: 11520680 by Gouge A., et al. Foxn4 - a new member of the forkhead gene family is expressed in the retina.
PMID: 15363391 by Li S., et al. Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors.