FLII Antibodies

AND FLII ELISA kits, FLII Proteins

Many biological assays use antibodies to detect FLII, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FLII in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FLII antibodies...

We validate the specificity of these antibodies to FLII by testing them on tissues known to express FLII positively and negatively. Browse below to find the FLII antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FLII Infographic by Boster Bio

All FLII Products

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Product

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Specificity

Applications

Price

Anti-Protein flightless-1 homolog FLII Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A02258
100ul

Flightless I (FLII) (NM_002018) Human Over-expression Lysate

Human

$628
Cat # LS002314
100 µg

FLII Overview

Facts about Protein flightless-1 homolog.

FLII 3D structure. Source: alphafold

Protein flightless-1 homolog (FLII)

May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling.

Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.

Gene Information

Human
Gene Name:	FLII
Uniprot:	Q13045
Entrez:	2314

Family

Belongs to:

No superfamily

Alternative Names

FLI; Fli1; flightless I homolog (Drosophila); FLILflightless I (Drosophila) homolog; MGC39265; protein flightless-1 homolog

Molecular Weight

Mass (kDA):
144.751 kDA

Genomic Context


Human

Location:	17p11.2
Sequence:	17; NC_000017.11 (18244815..18259022, complement)

Tissue Specificity

Strongest expression in skeletal muscle with high expression also in the heart and lung.

Subcellular Localizations

Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, focal adhesion. Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes (By similarity).

Diseases

Salmonella Infections
Neoplasms
Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)
Sarcoma
Tissue Adhesions
Malignant Neoplasms
Malignant Paraganglionic Neoplasm
Bone Neoplasms
Impaired Healing
Chromosomal Translocation
Neoplasm Metastasis
Neuroectodermal Tumors

Cell Invasion
Hyperplasia
Neuroectodermal Tumor, Primitive
T(11;22)(q24;q12)
Legionnaires' Disease
Cicatrix

Interacting Proteins

LRRFIP1

Pathways

Secretion
Wound Healing
Virulence
Protein Secretion
Cellularization
Transport
Localization
Response To Wounding
Proteolysis
Flight
Pathogenesis
Cell Migration
Swimming

Cell Cycle
Gastrulation
Regeneration
Cytokine Production
Cell Death
Cell Growth
Cell Adhesion

PTMs

Phosphorylation
Reduction

Glycosylation
Cleavage

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FLII

References

PMID: 9177775 by Campbell H.D., et al. Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL.

PMID: 8248259 by Campbell H.D., et al. The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans.