This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
MLANA Antibodies
AND MLANA ELISA kits, MLANA Proteins
Many biological assays use antibodies to detect MLANA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MLANA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MLANA antibodies...
Previous: CCN2
Next: FLNC
MLANA Infographic by Boster Bio
All MLANA Products
Product
Figures
Specificity
Applications
Price
Human, Horse
Flow Cytometry, IF, IHC
$486
Cat # M02033
100ug/vial
Cat # M02033
100ug/vial
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M02033-1
100 μl
Cat # M02033-1
100 μl
Human
IHC, WB
$431
Cat # M02033-2
100uL
Cat # M02033-2
100uL
Human
ELISA
$480
Cat # EKC1352
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1352
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA, Flow Cytometry, WB
$370
Cat # A02033-3
100 µg/vial
Cat # A02033-3
100 µg/vial
MLANA Overview
Facts about Melanoma antigen recognized by T-cells 1.
Melanoma antigen recognized by T-cells 1 (MLANA)
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which can be important to the formation of stage II melanosomes.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | MLANA |
| Uniprot: | Q16655 |
| Entrez: | 2315 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Antigen LB39-AA; Antigen SK29-AA; Mart 1 Melan A; MART-1; MART1MART-1; MelanA; Melan-A; melanoma antigen recognized by T-cells 1; MLANA; Protein Melan-A
Molecular Weight
Mass (kDA):
13.157 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p24.1 |
| Sequence: | 9; NC_000009.12 (5890889..5910606) |
Tissue Specificity
Expression is restricted to melanoma and melanocyte cell lines and retina.
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocyt
Diseases
- Melanoma
- Neoplasms
- Skin Neoplasms
- Malignant Neoplasms
- Neoplasm Metastasis
- Malignant Paraganglionic Neoplasm
- Metastatic Melanoma
- Lymphatic Metastasis
- Melanocytic Nevus
- Carcinoma
- Cutaneous Melanoma
- Influenza
Pathways
- Immune Response
- Secretion
- Melanocyte Differentiation
- Localization
- Pigmentation
- Cytokine Production
- Cell Differentiation
- Reverse Transcription
- Cell Proliferation
- Cytokine Secretion
- Hypersensitivity
- Cell Activation
- Sensitization
PTMs
- Phosphorylation
- Cleavage
- Biotinylation
- Methylation
Research Areas
- Cell Biology
- Cellular Markers
- Immunology
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MLANA
bosterbio.com/bosterbio-gene-info-cards/MLANA
References
PMID: 8170938 by Kawakami Y., et al. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.
PMID: 8006593 by Coulie P.G., et al. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.