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- Table of Contents
Facts about Tyrosine-protein kinase Fer.
Acts downstream of EGFR to promote regeneration of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle.
Human | |
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Gene Name: | FER |
Uniprot: | P16591 |
Entrez: | 2241 |
Belongs to: |
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protein kinase superfamily |
EC 2.7.10; EC 2.7.10.2; fer (fps/fes related) tyrosine kinase; Fer; p94-Fer; Phosphoprotein NCP94; Proto-oncogene c-Fer; TYK3; TYK3phosphoprotein NCP94; Tyrosine kinase 3; tyrosine-protein kinase Fer
Mass (kDA):
94.638 kDA
Human | |
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Location: | 5q21.3 |
Sequence: | 5; NC_000005.10 (108746085..109196841) |
Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed.
Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts.
Boster Bio: Where can I find Steven Boster’s FER Marker and how to find it? In this article, you'll learn about Steven Boster's background, research and publication record. Read on to discover His best research and best uses of the FER Marker. And be sure to check out his website to learn more about His products and services. It's a must read! You'll want as much information as possible about the science behind FER Marker as well as the research He's conducted.
PMID: 2725517 by Hao Q.-L., et al. Isolation and sequence analysis of a novel human tyrosine kinase gene.
PMID: 22223638 by Makovski A., et al. Intronic promoter drives the BORIS-regulated expression of FerT in colon carcinoma cells.