FDPS Antibodies

Farnesyl pyrophosphate synthase (FDPS)

Key enzyme in isoprenoid biosynthesis that catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation.

Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the consequent geranylpyrophosphate to the best product farnesyl pyrophosphate. .

Gene Information

Human
Gene Name:	FDPS
Uniprot:	P14324
Entrez:	2224

Family

Belongs to:
FPP/GGPP synthase family

Alternative Names

6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; EC 2.5.1.1; EC 2.5.1.10; farnesyl diphosphate synthaseFPP synthetase; farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase, dimethylallyltranstransferase; FPP synthase; FPPS; FPSgeranyltranstransferase; Geranyltranstransferase; KIAA1293

Molecular Weight

Mass (kDA):
48.275 kDA

Genomic Context

Human
Location:	1q22
Sequence:	1; NC_000001.11 (155308748..155320666)

Subcellular Localizations

Cytoplasm.

Diseases

• Malignant Neoplasms
• Osteoporosis
• Cholangiocarcinoma
• Neoplasms
• Osteoporosis, Postmenopausal
• Alzheimer's Disease
• Carcinoma
• Fibrosis
• Hyperinsulinism
• Diabetes Mellitus
• Diabetes Mellitus, Non-insulin-dependent
• Decreased Immunologic Activity [pe]
• Inflammation

• Cardiovascular Diseases
• Hyperglycemia
• Malignant Neoplasm Of Prostate
• Atherosclerosis
• Dyslipidemias
• Brain Ischemia
• Coronary Heart Disease

Pathways

• Transport
• Cell Proliferation
• Immune Response
• Translation
• Cholesterol Efflux
• Localization
• Methylation
• Bone Resorption
• Cholesterol Homeostasis
• Secretion
• Response To Paclitaxel
• Nuclear Export
• Cell Cycle

• Protein Geranylgeranylation
• Protein Import
• Cholesterol Transport
• Regulation Of Cholesterol Homeostasis
• Insulin Secretion
• Ion Transport
• Dna Methylation

PTMs

• Prenylation
• Farnesylation

• Geranylgeranylation
• Cleavage

• Oxidation

Research Areas

• Core ESC-Like Genes
• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FDPS

Boster Bio - Best Uses Of The FDPS Marker

When it comes to boster bio optimization guides, you can't go wrong. There are a variety of options available to you, including Boster Bio's Anti-CD68 (Macrophage Marker) monoclonal antibody. But if you're not sure which option is right for you, read on to find out more. There are also a number of product credits available for scientists who use boster bio.

Anti-CD68 (Macrophage Marker) monoclonal antibody

The Anti-CD68 (Macrophage) monoclonal antibody from Boster bio reacts with mouse CD68, also known as macrosialin. CD68 is a highly glycosylated type I integral membrane protein, related to sialomucins and Lysosomal/endosomal membrane glycoproteins. It is a commonly used pan-macrophage marker. Although its expression levels are low in conventional dendritic cells and Langerhans cells, it is widely used as a macrophage marker. While the anti-CD68 antibody reacts with CD68, most of the protein is localized in the lysosomal and endosome compartments, only a small fraction of CD68 circul

The Anti-CD68 monoclonal antibody from Boster Bio recognizes macrophages in both cultured and human cells. It is available in different sizes and in a variety of Alexa Fluor dyes. The anti-CD68 monoclonal antibody is highly specific for macrophages and is widely used in immunohistochemistry (IHC). For intracellular detection of CD68, permeabilization with a reagent such as LeucopermTM is recommended.

This antibody was previously described for the detection of CD68 in human blood cells. The antibody was developed in a goat and was produced in Wuhan, China. The secondary antibody was diluted 1:500 in PBS/BSA and applied to slides. Slides were then incubated for 30 minutes with the SABC complex, and the color was observed under a light microscope. After incubation with the secondary antibody, the specimens were washed under running water for 10 minutes, counterstained with Harris hematoxylin, and mounted in Permount resin.

CD68 is a member of the Scavenger Receptor family. It plays an important role in phagocytosis, the removal of oxidized LDL from the body. Its binding affinity to oxidized LDL facilitates phagocytosis. It is also an important part of the immune system. If you're looking for a monoclonal antibody against this molecule, you can rely on Boster Bio to provide excellent quality and exceptional service.

CAD patients with high levels of CD68-positive cells exhibit higher levels of macrophage infiltration than non-CAD patients. This may be due to FFA, a fatty substance that adipocytes produce. Besides, FFA is associated with an increase in macrophage-induced adipocyte lipolysis. Finally, adipocytes have high levels of CD68-positive cells in the epicardial adipose tissue of CAD patients. Both TNF-a and IL-6 increase in CAD patients, which may also be contributing to macrophage aggregation.

The Anti-CD68 monoclonal antibody from Boster Bio can be used for many different applications. However, it is not suitable for immunohistochemistry on frozen tissue sections and should be stored at 4 degrees C. It should also be microcentrifuged before use to avoid antibody degradation. The shelf life of the antibody is 18 months if properly stored. However, you should note that the anti-CD68 antibody will become embedded in the vial seal over time. This may necessitate the purchase of dry ice.

Using the anti-CD68 monoclonal antibody from Boster Bio for immunohistochemistry studies is a great way to identify a specific cell type. The antibodies used in immunohistochemistry are obtained through immunization with synthetic and purified peptides. To confirm their effectiveness, the antibodies were tested against cultured macrophages and monocyte-derived macrophages by FACS.

FDPS marker

FDPS is an important biomarker used for studying inflammatory diseases, such as hepatitis and diabetes. Researchers can use the marker in a variety of applications, including animal studies and human clinical trials. Its use is widely used in biomedical research, such as in drug development and cancer treatment. Researchers worldwide can submit their results to gain product credits and receive scientific recognition for their work.