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FCGR2B Antibodies
AND FCGR2B ELISA kits, FCGR2B Proteins
Many biological assays use antibodies to detect FCGR2B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FCGR2B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FCGR2B antibodies...
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FCGR2B Infographic by Boster Bio
All FCGR2B Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$500
Cat # EZ1312
For 5 plates, 96 wells each
Cat # EZ1312
For 5 plates, 96 wells each
Human, Mouse, Rat
ELISA
$480
Cat # EKC1100
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1100
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2147
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2147
1 kit, containing two 96-well plates and all necessary reagents
Human
ELISA
$499
Cat # FEK1312
96 wells/kit, with removable strips.
Cat # FEK1312
96 wells/kit, with removable strips.
FCGR2B Overview
Facts about Low affinity immunoglobulin gamma Fc region receptor II-b.
Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B)
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor.
Involved in many different effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of earlier state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or through another Fc receptor.
Gene Information
| Human | |
|---|---|
| Gene Name: | FCGR2B |
| Uniprot: | P31994 |
| Entrez: | 2213 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD32 antigen; CD32b; CD32Fc fragment of IgG, low affinity II, receptor for (CD32); CDw32; Fc fragment of IgG, low affinity IIb, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc gamma RIIB; FCG2; Fc-gamma RII-b; fc-gamma-RIIb; FCGR2; FCGR2B; FcgRIIB; FCRIIB; fcRII-b; IGFR2; IgG Fc receptor II-b; low affinity immunoglobulin gamma Fc region receptor II-b
Molecular Weight
Mass (kDA):
34.044 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.3 |
| Sequence: | 1; NC_000001.11 (161647243..161678654) |
Tissue Specificity
Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.
Diseases
- Autoimmune Reaction
- Lupus Erythematosus, Systemic
- Autoimmune Diseases
- Autoimmunity
- Inflammation
- Arthritis
- Rheumatoid Arthritis
- Purpura, Thrombocytopenic, Idiopathic
- Glomerulonephritis
- Lymphoma
- Neoplasms
- Dysequilibrium Syndrome
- Nephritis
Interacting Proteins
- IGHG1
- INPP5D
- NCK1
- PLCG1
- PTPN6
Pathways
- Pathogenesis
- Cell Activation
- Immune Response
- B Cell Activation
- Phagocytosis
- Anaphylaxis
- Secretion
- Cell Differentiation
- Adaptive Immune Response
- Cell Proliferation
- B Cell Differentiation
- Inflammatory Response
- Sensitization
PTMs
- Phosphorylation
- Dephosphorylation
- Biotinylation
Research Areas
- Immunology
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FCGR2B
bosterbio.com/bosterbio-gene-info-cards/FCGR2B
References
PMID: 2531080 by Stuart S.G., et al. Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.
PMID: 2529342 by Brooks D.G., et al. Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.