Espin Antibodies

AND Espn ELISA kits, Espin Proteins

Many biological assays use antibodies to detect Espin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Espin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Espin antibodies...

We validate the specificity of these antibodies to Espin by testing them on tissues known to express Espn positively and negatively. Browse below to find the Espn antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Espn Infographic by Boster Bio

All Espn Products

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Espin (ESPN) (NM_031475) Human Recombinant Protein

$1062
Cat # PROTB1AK53
20 µg

Espin (ESPN) (NM_031475) Human Over-expression Lysate

Human

$960
Cat # LS083715
100 µg

Espn Overview

Facts about Espin.

Espin (Espn)

Multifunctional actin-bundling protein. Plays a significant role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli from the mechanosensory and chemosensory cells (PubMed:14657236, PubMed:15190118).

Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a vital role in the formation and maintenance of inner ear hair cell stereocilia (PubMed:21455486).

Gene Information

Mouse
Gene Name:	Espn
Uniprot:	Q9ET47
Entrez:	56226

Family

Belongs to:

No superfamily

Alternative Names

autosomal recessive deafness type 36 protein; DKFZp434A196; DKFZp434G2126; espin

Molecular Weight

Mass (kDA):
94.497 kDA

Genomic Context


Mouse

Location:	4 E2\|4 82.9 cM
Sequence:	4;

Tissue Specificity

Expressed at high concentration in the microvillar parallel actin bundle (PAB) of hair cells stereocilia in the cochlea and vestibular system. Detected also at high levels of a number of other sensory cell types, including taste receptor cells, solitary chemoreceptor cells, vomeronasal sensory neurons and Merkel cells. Isoforms 2, 3, 4 and 5 are expressed in Purkinje cells dendritic spines. Expressed in utricle hair bundles (at protein level) (PubMed:26926603).

Diseases

Complete Hearing Loss
Kidney Diseases
Kidney Failure, Chronic
Kidney Failure
Hypertensive Disease
Brain Neoplasms
Vestibular Diseases
Mutation, Out-of-frame
Deafness Congenital
Respiration Disorders
Fracture
Cardiovascular Diseases

Hip Fractures
Chronic Disease/disorder
Bartter Disease
Fanconi Syndrome
Uremia Syndrome
Intertrochanteric Fracture

Pathways

Spermatogenesis
Cell Adhesion
Germ Cell Development
Cell Development
Localization
Meiosis

Cell Maturation

PTMs

Amination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Espn

References

PMID: 10975527 by Zheng L., et al. The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins.

PMID: 12598619 by Sekerkova G., et al. Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53.