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, No Gclids
Espin Antibodies
AND Espn ELISA kits, Espin Proteins
Many biological assays use antibodies to detect Espin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Espin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Espin antibodies...
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Espn Overview
Facts about Espin.
Espin (Espn)
Multifunctional actin-bundling protein. Plays a significant role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli from the mechanosensory and chemosensory cells (PubMed:14657236, PubMed:15190118).
Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a vital role in the formation and maintenance of inner ear hair cell stereocilia (PubMed:21455486).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Espn |
| Uniprot: | Q9ET47 |
| Entrez: | 56226 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
autosomal recessive deafness type 36 protein; DKFZp434A196; DKFZp434G2126; espin
Molecular Weight
Mass (kDA):
94.497 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 4 E2|4 82.9 cM |
| Sequence: | 4; |
Tissue Specificity
Expressed at high concentration in the microvillar parallel actin bundle (PAB) of hair cells stereocilia in the cochlea and vestibular system. Detected also at high levels of a number of other sensory cell types, including taste receptor cells, solitary chemoreceptor cells, vomeronasal sensory neurons and Merkel cells. Isoforms 2, 3, 4 and 5 are expressed in Purkinje cells dendritic spines. Expressed in utricle hair bundles (at protein level) (PubMed:26926603).
Diseases
- Complete Hearing Loss
- Kidney Diseases
- Kidney Failure, Chronic
- Kidney Failure
- Hypertensive Disease
- Brain Neoplasms
- Vestibular Diseases
- Mutation, Out-of-frame
- Deafness Congenital
- Respiration Disorders
- Fracture
- Cardiovascular Diseases
Pathways
- Spermatogenesis
- Cell Adhesion
- Germ Cell Development
- Cell Development
- Localization
- Meiosis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Espn
bosterbio.com/bosterbio-gene-info-cards/Espn
References
PMID: 10975527 by Zheng L., et al. The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins.
PMID: 12598619 by Sekerkova G., et al. Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53.