ERCC5 Antibodies

AND ERCC5 ELISA kits, ERCC5 Proteins

Many biological assays use antibodies to detect ERCC5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ERCC5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ERCC5 antibodies...

We validate the specificity of these antibodies to ERCC5 by testing them on tissues known to express ERCC5 positively and negatively. Browse below to find the ERCC5 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ERCC5 Infographic by Boster Bio

All ERCC5 Products

Product

Figures

Specificity

Applications

Price

Anti-ERCC5/Xpg Antibody

5 Q&As

Human

$360
Cat # A01770
100 µl

ERCC5 Colorimetric Cell-Based ELISA

Human

ELISA

$480
Cat # EKC1703
1 kit, containing one 96-well plate and all necessary reagents

Anti-ERCC5/XPG (E160) Antibody

Human

IHC, WB

$405
Cat # A01770-1
100ul

ERCC5 Overview

Facts about DNA repair protein complementing XP-G cells.

ERCC5 3D structure. Source: alphafold

DNA repair protein complementing XP-G cells (ERCC5)

Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER).

Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled fix of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.

Gene Information

Human
Gene Name:	ERCC5
Uniprot:	P28715
Entrez:	2073

Family

Belongs to:

XPG/RAD2 endonuclease family

Alternative Names

COFS3; DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells; EC 3.1; ERCM2; excision repair cross-complementing rodent repair deficiency, complementationgroup 5; excision repair protein; xeroderma pigmentosum complementation group G protein; Xeroderma pigmentosum group G-complementing protein; xeroderma pigmentosum, complementation group G; XPGC; XPG-complementing protein; XPGUVDR

Molecular Weight

Mass (kDA):
133.108 kDA

Genomic Context


Human

Location:	13q33.1
Sequence:	13; NC_000013.11 (102846032..102875995)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Xeroderma Pigmentosum
Xeroderma
Malignant Neoplasm Of Lung
Carcinoma
Lung Neoplasms
Xeroderma Pigmentosum, Group G
Malignant Neoplasm Of Breast
Malignant Squamous Cell Neoplasm
Cholangiocarcinoma
Cytogenetic Abnormality
Head And Neck Neoplasms

Mammary Neoplasms
Colorectal Neoplasms
Carcinogenesis
Cockayne Syndrome
Xeroderma Pigmentosum Complementation Group A
Malignant Neoplasm Of Ovary
Colorectal Cancer

Interacting Proteins

GADD45A

Pathways

Dna Repair
Dna Excision
Cell Proliferation
Mismatch Repair
Cell Cycle
Double-strand Break Repair
Localization
Transport
Reverse Transcription
Translation
Nucleotide-excision Repair
Drug Resistance
Cell Death

Cell Growth
Pathogenesis
Base-excision Repair
Dna Alkylation
Response To Gamma Radiation
Immune Response
Hypersensitivity

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERCC5

References

PMID: 8483504 by Scherly D., et al. Complementation of the DNA repair defect in Xeroderma pigmentosum group G cells by a human cDNA related to yeast RAD2.

PMID: 7510366 by Shiomi T., et al. An ERCC5 gene with homology to yeast RAD2 is involved in group G Xeroderma pigmentosum.