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- Table of Contents
Facts about Histone-lysine N-methyltransferase EZH1.
Able to mono-, di- and trimethylate'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved with protecting embryonic stem cell identity.
Human | |
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Gene Name: | EZH1 |
Uniprot: | Q92800 |
Entrez: | 2145 |
Belongs to: |
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class V-like SAM-binding methyltransferase superfamily |
EC 2.1.1.43; enhancer of zeste homolog 1 (Drosophila); Enhancer of zeste homolog 1; ENX-2; histone-lysine N-methyltransferase EZH1; KIAA0388enhancer of zeste (Drosophila) homolog 1; KMT6B
Mass (kDA):
85.271 kDA
Human | |
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Location: | 17q21.2 |
Sequence: | 17; NC_000017.11 (42700275..42745078, complement) |
Nucleus. Colocalizes with trimethylated 'Lys-27' of histone H3.
PMID: 8921387 by Abel K.J., et al. Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1.
PMID: 9473645 by Ogawa M., et al. Cloning and expression of a human/mouse Polycomb group gene, ENX- 2/Enx-2.