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- Table of Contents
Facts about Steroid hormone receptor ERR2.
Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer website of ELF5 and EOMES and activating their transcription resulting in self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity).
Human | |
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Gene Name: | ESRRB |
Uniprot: | O95718 |
Entrez: | 2103 |
Belongs to: |
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nuclear hormone receptor family |
ERR beta; ERR2; ESRL2; ESRRB; estrogen-related receptor beta; NR3B2
Mass (kDA):
48.054 kDA
Human | |
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Location: | 14q24.3 |
Sequence: | 14; NC_000014.9 (76371347..76501839) |
Nucleus. Cytoplasm. Chromosome.
PMID: 10072763 by Chen F., et al. Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR.
PMID: 16332939 by Zhou W., et al. Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta.