EP300 Antibodies

AND EP300 ELISA kits, EP300 Proteins

Many biological assays use antibodies to detect EP300, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EP300 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EP300 antibodies...

We validate the specificity of these antibodies to EP300 by testing them on tissues known to express EP300 positively and negatively. Browse below to find the EP300 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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EP300 Infographic by Boster Bio

All EP300 Products

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Product

Figures

Specificity

Applications

Price

Anti-KAT3B/p300/EP300 Antibody Picoband®

1 Citations 12 Q&As

Human, Mouse, Rat

IHC, WB

$370
Cat # PB9178
100 μg/vial

p300 Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$480
Cat # EKC1420
1 kit, containing one 96-well plate and all necessary reagents

Anti-Phospho-p300 (S89) EP300 Antibody

Human, Mouse, Rat

ELISA, IHC

$380
Cat # A00117S89
100ul

Anti-KAT3B/p300/EP300 Antibody Picoband®

1 Citations

Human, Mouse

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A00117
100 μg/vial

EP300 (NM_001429) Human Over-expression Lysate

Human

$960
Cat # LS002033
100 µg

EP300 Overview

Facts about Histone acetyltransferase p300.

EP300 3D structure. Source: alphafold

Histone acetyltransferase p300 (EP300)

Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521).

Mediates acetylation of histone H3 at'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at'Lys-27' (H3K27ac) (PubMed:23911289).

Gene Information

Human
Gene Name:	EP300
Uniprot:	Q09472
Entrez:	2033

Family

Belongs to:

No superfamily

Alternative Names

E1A binding protein p300; E1A-associated protein p300; E1A-binding protein, 300kD; EC 2.3.1; EC 2.3.1.48; EP300; histone acetyltransferase p300; KAT3B; p300 HAT; p300; RSTS2

Molecular Weight

Mass (kDA):
264.161 kDA

Genomic Context


Human

Location:	22q13.2
Sequence:	22; NC_000022.11 (41092592..41180077)

Subcellular Localizations

Cytoplasm. Nucleus. Chromosome. Localizes to active chromatin: Colocalizes with histone H3 acetylated and/or crotonylated at 'Lys-18' (H3K18ac and H3K18cr, respectively) (PubMed:25818647). In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Colocalizes with ROCK2 in the nucleus (PubMed:12929931).

Diseases

Neoplasms
Malignant Neoplasms
Carcinoma
Leukemia
Cell Transformation, Neoplastic
Mammary Neoplasms
Inflammation
Malignant Neoplasm Of Breast
Rubinstein-taybi Syndrome
Hypoxia
Retinoblastoma
Hypertrophy

Chromosomal Translocation
Myeloid Leukemia
Malignant Paraganglionic Neoplasm
Leukemia, Myelocytic, Acute
Liver Carcinoma
Lymphoma
Tissue Adhesions

Interacting Proteins

ALKBH4
APEX1
ASH2L
AUTS2
BRD7

CDK2
CITED2
COPS2
CREB1
Creb1

DDX5
ESR1
EWSR1
FUS
GTF2B

HIF1A
Hif1a
HIPK2
Jmy
KAT2B

NAP1L1
NBN
NCOA3
POU3F2
PPP1R13B

PPP1R13L
RUNX3
SIRT1
SKP2
SNAI1

STAT6
TBX21
TCL1A
TFAP2A
TP53

TP53BP2
TP73
VDR
YBX1

Pathways

Cell Cycle
Histone Acetylation
Localization
Cell Differentiation
Cell Proliferation
Cell Growth
Pathogenesis
Cell Death
Chromatin Remodeling
Cell Cycle Arrest
Methylation
S Phase
Regulation Of Gene Expression

Dna Repair
Histone Modification
Secretion
Rna Interference
Cell Adhesion
Histone H4 Acetylation
Cell Development

PTMs

Acetylation
Phosphorylation
Deacetylation
Methylation
Ubiquitination
Cleavage

Sumoylation
Demethylation
Dephosphorylation
Nitrosylation
Hydroxylation
Ribosylation

Research Areas

Apoptosis
Autophagy
Breast Cancer
Cancer
Cell Cycle and Replication

Cellular Markers
Chromatin Research
DNA Repair
HIF Target Genes
Hypoxia

Stem Cell Markers
Transcription Factors and Regulators
Tumor Suppressors
Wnt Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EP300

References

PMID: 7523245 by Eckner R., et al. Molecular cloning and functional analysis of the adenovirus E1A- associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

PMID: 10824998 by Chaffanet M., et al. MOZ is fused to p300 in an acute monocytic leukemia with t(8;22).

2 Publications of Boster EP300 Antibodies & ELISA Kits

PubMed ID: 10.1016/j.scib.2021.01.027, MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in blad...
PubMed ID: 10.1007/s11655-011-0693-3, Effect of artemisinin combined with glucocorticoid on the expressions of glucoco...

*More publications can be found for each product on its corresponding product page