EIF5 Antibodies

Eukaryotic translation initiation factor 5 (EIF5)

Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.

Met-tRNA[F].eIF-2.

Gene Information

Human
Gene Name:	EIF5
Uniprot:	P55010
Entrez:	1983

Family

Belongs to:
eIF-2-beta/eIF-5 family

Alternative Names

eIF-5; EIF-5A; eukaryotic translation initiation factor 5

Molecular Weight

Mass (kDA):
49.223 kDA

Genomic Context

Human
Location:	14q32.32
Sequence:	14; NC_000014.9 (103334237..103345025)

Diseases

• Punctate Inner Choroidopathy
• Hepatitis
• Malignant Neoplasms
• Neoplasms
• Hepatitis C
• Carcinoma
• Leukemia
• Malnutrition
• Leukoencephalopathies
• Hepatitis, Viral, Animal
• Carcinoma 256, Walker
• Hepatitis B

• Myeloid Leukemia, Chronic
• Leukoencephalopathy With Vanishing White Matter
• Myeloid Leukemia
• Acute Promyelocytic Leukemia
• Cachexia
• Viral Hepatitis
• Colorectal Cancer

Interacting Proteins

• DUSP12

Pathways

• Translation
• Cell Growth
• Cell Cycle
• Cell Proliferation
• Regulation Of Translation
• Regulation Of Cell Cycle
• Proteolysis
• Transport
• Translational Initiation
• M Phase
• Response To Starvation
• Localization
• Nuclear Export

• Disease Resistance
• Myeloid Cell Differentiation
• Cell Division
• Ribosome Biogenesis
• Reverse Transcription
• Cell Death
• Cell Differentiation

PTMs

• Phosphorylation

• Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EIF5

Boster Bio - Best Uses Of The EIF5 Marker

The boster protein capture technique was developed with the use of an anti-DDK affinity column. The boster protein capture procedure is applicable to all scientists world-wide. In this article, we will discuss its application and the best use for the EIF5 marker. To learn more about boster protein capture, please visit the boster bio website. This site also contains a listing of related proteins.

NDRG1

The EIF5 Marker is a protein found in eukaryotic cells. When this protein is depleted, cells can undergo metabolic re-initiation, proliferation, and DNA damage. The protein functions as a translatome remodeler, suppressing metabolism to protect the genome. It has been associated with multiple diseases, such as cancer. Here are the best uses of this protein in the biology field.

The eIF5A gene is related to the LUCA33, a cellular enzyme that evolved under anoxic conditions and resorted to anaerobic metabolism. Its retention in modern eukaryotes is a reflection of this adaptation. Anaerobic conditions activate a special translational program to respond to the lack of oxygen. Historically, these conditions have been viewed as inhibitors to protein synthesis. The discovery of the eIF5A gene highlights the importance of global translational reprogramming as a central mechanism in adaptation.

eIF5A is a highly conserved protein that is necessary for cell survival. It may also serve as a proliferative brake by inhibiting cellular growth. Anaerobic acidosis increases DNA and chromosomal damage. Cells with eIF5A-competent gene expression effectively maintained genomic integrity during acidosis. eIF5A-deficient cells had increased DNA and chromosomal damage.

TSC2

The Boster Bio Anti-EIF5B Antibody (catalog number A30685) reacts with Human, Mouse and Rat. This product is for scientific research. It can be used in a variety of applications and special samples. Scientists from all over the world can submit their results and earn product credits. They can also submit their results for special species and applications. There are many benefits to using the Boster Bio Anti-EIF5B antibody.

Junc2

Using the EIF5 marker for research purposes can help you better understand the function of this protein. This marker helps in determining if a cell is healthy or sick. The protein acts as a translatome remodeler, which inhibits metabolism to protect the genome. If there is a depletion of eIF5A, tumor cells may be resistant to conventional antiproliferative drugs and grow rapidly. Targeting this protein can improve the efficacy of conventional antiproliferative drugs.

The eIF5A gene is related to the LUCA33 gene. This gene, whose evolutionary origins are unclear, is responsible for anaerobic adaptation. Under anoxic conditions, cells activate a dedicated translational program. Although anoxic conditions are commonly thought to inhibit protein synthesis, eIF5A highlights the central role of global translational reprogramming in adaptation.

Nfkb2

To understand the role of EIF5B, the human genome must be sequenced. This gene is a crucial regulator of cell growth and proliferation, and depletion of this protein results in cell proliferation and DNA damage. It acts as a translatome remodeler, suppressing metabolism in response to the needs of the genome. In addition, it is important for regulating cellular signaling, and may be used to understand how cells use energy.

In cancer, eIF5A has an important role in regulating cellular growth. The protein might even act as a proliferative brake. Anaerobic acidosis, which increases DNA and chromosomal damage, is known to induce eIF5A-competent cells to maintain genomic integrity. Likewise, cells knocked down of eIF5A showed a significant increase in DNA damage.

The eIF5A molecule has a history dating back to LUCA33, which evolved in anaerobic environments and relied on anaerobic metabolism. Anaerobic conditions trigger cells to activate a dedicated translational program, and eIF5A highlights global translational reprogramming as a central mechanism of adaptation.

Junc3

If you're in the process of developing a new antibody for the discovery of EIF5 and other proteins, you need to use a reliable source of boster protein capture. Boster antibodies are high-affinity and well-validated for Western Blotting, Immunohistochemistry, and ELISA. Their use in biomedical research will benefit the entire scientific community.