Ephrin-A3 (EFNA3)

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases that are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, resulting in contact-dependent bidirectional signaling into neighboring cells.

The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). .