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- Table of Contents
Facts about Ephrin-A2.
The signaling pathway downstream of the receptor is known as forward signaling while the signaling pathway downstream of the ephrin ligand is known as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity).
Human | |
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Gene Name: | EFNA2 |
Uniprot: | O43921 |
Entrez: | 1943 |
Belongs to: |
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ephrin family |
Cek7-L; EFNA2; ELF-1; EPH-related receptor tyrosine kinase ligand 6; EphrinA2; Ephrin-A2; EPLG6HEK7 ligand; HEK7-L; HEK7-ligand; LERK6; LERK6LERK-6; ligand of eph-related kinase 6
Mass (kDA):
23.878 kDA
Human | |
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Location: | 19p13.3 |
Sequence: | 19; NC_000019.10 (1282817..1301431) |
Cell membrane; Lipid-anchor, GPI-anchor.
PMID: 9465306 by Cerretti D.P., et al. Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure.
PMID: 9826538 by Aasheim H.-C., et al. Cloning, chromosomal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2.