This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Ephrin-A1.
Plays an essential role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and gathering.
Human | |
---|---|
Gene Name: | EFNA1 |
Uniprot: | P20827 |
Entrez: | 1942 |
Belongs to: |
---|
ephrin family |
B61; ECKLG; EFL1; EFL-1; EFNA1; EPH-related receptor tyrosine kinase ligand 1; EphrinA1; Ephrin-A1; EPLG1TNF alpha-induced protein 4; Immediate early response protein B61; LERK1; LERK1LERK-1; ligand of eph-related kinase 1; TNFAIP4B61; Tumor necrosis factor alpha-induced protein 4; tumor necrosis factor, alpha-induced protein 4
Mass (kDA):
23.787 kDA
Human | |
---|---|
Location: | 1q22 |
Sequence: | 1; NC_000001.11 (155127876..155134899) |
Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
Cell membrane; Lipid-anchor, GPI-anchor.; [Ephrin-A1, secreted form]: Secreted.
PMID: 2233719 by Holzman L.B., et al. A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein.
PMID: 7838529 by Kozlosky C.J., et al. Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.