This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Endothelin-1 receptor Antibodies
AND EDNRA ELISA kits, Endothelin-1 receptor Proteins
Many biological assays use antibodies to detect Endothelin-1 receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Endothelin-1 receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Endothelin-1 receptor antibodies...
Previous: CCN2
Next: PHC1
EDNRA Infographic by Boster Bio
All EDNRA Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01828-4
100 μg/vial
Cat # A01828-4
100 μg/vial
Human
$628
Cat # LS001909
100 µg
Cat # LS001909
100 µg
EDNRA Overview
Facts about Endothelin-1 receptor.
Endothelin-1 receptor (EDNRA)
Receptor for endothelin-1.
Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. .
Gene Information
| Human | |
|---|---|
| Gene Name: | EDNRA |
| Uniprot: | P25101 |
| Entrez: | 1909 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
EDNRA; endothelin receptor type A; endothelin-1 receptor; endothelin-1-specific receptor; ET1-specific type; ETAR; ETRA; G protein-coupled receptor; hET-AR
Molecular Weight
Mass (kDA):
48.722 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q31.22-q31.23 |
| Sequence: | 4; NC_000004.12 (147480917..147544954) |
Tissue Specificity
Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Crest Syndrome
- Hypertensive Disease
- Malignant Neoplasms
- Neoplasms
- Migraine Disorders
- Cholangiocarcinoma
- Pathologic Vasoconstriction
- Hypoxia
- Migraine With Aura
- Congenital Abnormality
- Lung Diseases
- Headache
- Inflammation
Interacting Proteins
- ARRB1
- ARRB2
- EDN1
Pathways
- Cell Proliferation
- Localization
- Pigmentation
- Vasoconstriction
- Cell Migration
- Luteolysis
- Ovulation
- Cellular Localization
- Pathogenesis
- Transport
- Developmental Process
- Fertilization
- Lung Development
PTMs
Research Areas
- GPCR
- Neuroscience
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EDNRA
bosterbio.com/bosterbio-gene-info-cards/EDNRA
References
PMID: 1719979 by Adachi M., et al. Cloning and characterization of cDNA encoding human A-type endothelin receptor.
PMID: 1659806 by Cyr C., et al. Cloning and chromosomal localization of a human endothelin ETA receptor.
4 Publications of Boster Endothelin-1 receptor Antibodies & ELISA Kits
- PubMed ID: 10.1111/jphp.12517, Exogenous hydrogen sulphide ameliorates diabetic cardiomyopathy in rats by rever...
- PubMed ID: 10.1111/j.2042-7158.2011.01268.x, Sildenafil improves diabetic vascular activity through suppressing endothelin re...
- PubMed ID: 10.1007/s10571-009-9399-x, Expression and Localization of Endothelin-1 and its Receptors in the Spiral Gang...
- PubMed ID: 20167215, Peng Hj, Dai Dz, Ji H, Dai Y. Eur J Pharmacol. 2010 May 25;634(1-3):101-6. Doi: ...
*More publications can be found for each product on its corresponding product page