DYRK1A Antibodies

AND DYRK1A ELISA kits, DYRK1A Proteins

Many biological assays use antibodies to detect DYRK1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DYRK1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DYRK1A antibodies...

We validate the specificity of these antibodies to DYRK1A by testing them on tissues known to express DYRK1A positively and negatively. Browse below to find the DYRK1A antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DYRK1A Infographic by Boster Bio

All DYRK1A Products

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Product

Figures

Specificity

Applications

Price

Anti-DYR1A DYRK1A Antibody

17 Q&As

Human, Mouse, Rat

ELISA, IF, IHC-P, ICC, WB

$335
Cat # A30487
100ul

Anti-DYRK1A Antibody Picoband®

16 Q&As

Human, Rat

ELISA, IF, ICC, WB

$370
Cat # A00878-1
100 μg/vial

DYR1A Colorimetric Cell-Based ELISA

Human, Mouse, Rat

ELISA

$480
Cat # EKC1804
1 kit, containing one 96-well plate and all necessary reagents

Anti-Dyrk1A (Q39) Antibody

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A00878
100ul

Rat DYRK1A Recombinant Protein

SDS-PAGE, Denatured

$250
Cat # PROTQ63470
Starting from 20ug

DYRK1A (NM_130436) Human Over-expression Lysate

Human

$960
Cat # LS001859
100 µg

DYRK1A Overview

Facts about Dual specificity tyrosine-phosphorylation-regulated kinase 1A.

DYRK1A 3D structure. Source: alphafold

Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell regeneration.

Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process.

Gene Information

Human
Gene Name:	DYRK1A
Uniprot:	Q13627
Entrez:	1859

Family

Belongs to:

protein kinase superfamily

Alternative Names

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; DYRK1; DYRK1A; MNBEC 2.7.110EC 2.7.12; MNBH

Molecular Weight

Mass (kDA):
85.584 kDA

Genomic Context


Human

Location:	21q22.13
Sequence:	21; NC_000021.9 (37365573..37526358)

Tissue Specificity

Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.

Subcellular Localizations

Nucleus. Nucleus speckle.

Diseases

Down Syndrome
Trisomy
Alzheimer's Disease
Malignant Neoplasms
Neoplasms
Neurofibrillary Tangles
Neurodegenerative Disorders
Nerve Degeneration
Nervousness
Dementia
Partial Trisomy
Microcephaly

Memory Impairment
Cell Transformation, Neoplastic
Haploinsufficiency
Leukemia
Hypertrophy
Neuropathology Disease

Interacting Proteins

DCAF7
LZTS2
RB1
RBL1
TROAP

YWHAB

Pathways

Brain Development
Neurogenesis
Localization
Pathogenesis
Cell Cycle
Cell Death
Cell Proliferation
Hyperphosphorylation
Rna Interference
Aging
Translation
Mitosis
Senescence

Cell Growth
Cell Migration
Cell Division
Oocyte Maturation
Endocytosis
Clathrin-mediated Endocytosis
Cell Differentiation

PTMs

Phosphorylation
Dephosphorylation
Cleavage

Deacetylation
Acetylation
Methylation

Ubiquitination

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DYRK1A

References

PMID: 8975710 by Song W.J., et al. Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome 'critical region'.

PMID: 8872470 by Guimera J., et al. A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region.