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Torsin-1A Antibodies
AND TOR1A ELISA kits, Torsin-1A Proteins
Many biological assays use antibodies to detect Torsin-1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Torsin-1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Torsin-1A antibodies...
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TOR1A Infographic by Boster Bio
All TOR1A Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, WB
$370
Cat # M01381
100 μl
Cat # M01381
100 μl
TOR1A Overview
Facts about Torsin-1A.
Torsin-1A (TOR1A)
Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN).
In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism appears to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and might regulate the subcellular location of multipass membrane proteins like the dopamine transporter SLC6A3, causing the modulation of dopamine neurotransmission.
Gene Information
| Human | |
|---|---|
| Gene Name: | TOR1A |
| Uniprot: | O14656 |
| Entrez: | 1861 |
Family
| Belongs to: |
|---|
| ClpA/ClpB family |
Alternative Names
DQ2Torsin family 1 member A; Dystonia 1 protein; dystonia 1, torsion (autosomal dominant; torsin A); DYT1torsin-1A; torsin family 1, member A (torsin A)
Molecular Weight
Mass (kDA):
37.809 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q34.11 |
| Sequence: | 9; NC_000009.12 (129812942..129824136, complement) |
Tissue Specificity
Widely expressed. Highest levels in kidney and liver. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also highly expressed in the spinal cord.
Subcellular Localizations
Endoplasmic reticulum lumen. Nucleus membrane; Peripheral membrane protein. Cell projection, growth cone. Cytoplasmic vesicle membrane. Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasm, cytoskeleton. Upon oxidative stress, redistributes to protusions from the cell surface (By similarity). Peripherally associated with the inner face of the ER membrane, probably mediated by the interaction with TOR1AIP1. The association with nucleus membrane is mediated by the interaction with TOR1AIP2.
Diseases
- Dystonia Disorders
- Dystonia Musculorum Deformans
- Movement Disorders
- Dystonia, Primary
- Generalized Dystonia
- Globus Hystericus
- Myoclonus
- Focal Dystonia
- Parkinson Disease
- Dystonia 1, Torsion, Autosomal Dominant
- Muscle Cramp
- Organic Writer's Cramp
Interacting Proteins
- KRTAP10-7
Pathways
- Localization
- Pathogenesis
- Secretory Pathway
- Transport
- Protein Folding
- Secretion
- Neurogenesis
- Reflex
- Membrane Depolarization
- Response To Stress
- Locomotion
- Protein Processing
- Autophagy
PTMs
- Glycosylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TOR1A
bosterbio.com/bosterbio-gene-info-cards/TOR1A
References
PMID: 9288096 by Ozelius L.J., et al. The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein.
PMID: 10871631 by Kustedjo K., et al. Torsin A and its torsion dystonia-associated mutant forms are lumenal glycoproteins that exhibit distinct subcellular localizations.