DUT Antibodies

AND DUT ELISA kits, DUT Proteins

Many biological assays use antibodies to detect DUT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DUT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DUT antibodies...

We validate the specificity of these antibodies to DUT by testing them on tissues known to express DUT positively and negatively. Browse below to find the DUT antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DUT Infographic by Boster Bio

All DUT Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-DUT Antibody Picoband®

7 Q&As

Human, Mouse, Rat

IHC, WB

$370
Cat # PA1030-1
100 μg/vial

DUT (NM_001025249) Human Recombinant Protein

$813
Cat # PROTP33316
20 µg

DUT (NM_001948) Human Over-expression Lysate

Human

$628
Cat # LS001854
100 µg

Anti-DUT Rabbit Monoclonal Antibody

Human

Flow Cytometry, IF, ICC, WB

$370
Cat # M04280
100 µl/vial

DUT Overview

Facts about Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial.

DUT 3D structure. Source: alphafold

Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT)

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil can't be incorporated into DNA. .

Gene Information

Human
Gene Name:	DUT
Uniprot:	P33316
Entrez:	1854

Family

Belongs to:

dUTPase family

Alternative Names

deoxyuridine triphosphatase; dUTP pyrophosphatasedUTP nucleotidohydrolase; dUTPasedeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; EC 3.6.1.23; FLJ20622

Molecular Weight

Mass (kDA):
26.563 kDA

Genomic Context


Human

Location:	15q21.1
Sequence:	15; NC_000015.10 (48329991..48343373)

Tissue Specificity

Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level).

Subcellular Localizations

[Isoform 2]: Nucleus.; [Isoform 3]: Mitochondrion.

Diseases

Malignant Neoplasms
Neoplasms
Infective Disorder
Lupus Erythematosus, Systemic
Acquired Immunodeficiency Syndrome
Benign Prostatic Hypertrophy
Ulcer
Prostatic Hyperplasia
Pancreatitis
Malignant Neoplasm Of Prostate
Tissue Adhesions
Hypertensive Disease

Hyperplasia
Aneurysm
Carcinoma
Chromosome Breakage
Mammary Neoplasms
Chimera Disorder
Cancer Patients And Suicide And Depression

Interacting Proteins

NUDT18

Pathways

Dna Replication
Dna Repair
Pathogenesis
Transport
Reverse Transcription
Cell Cycle
Localization
Viral Replication
Programmed Cell Death
Aging
Immune Response
Diuresis
Nuclear Export

Sensitization
Segmentation
Recombinational Repair
Cell Proliferation
Prepulse Inhibition
Cellular Process
Muscle Adaptation

PTMs

Cleavage

Deamination

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DUT

References

PMID: 8631816 by Ladner R.D., et al. Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase.

PMID: 9070952 by Cohen D., et al. Assignment of the human dUTPase gene (DUT) to chromosome 15q15-q21. 1 by fluorescence in situ hybridization.