This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Draxin Antibodies
AND Draxin ELISA kits, Draxin Proteins
Many biological assays use antibodies to detect Draxin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Draxin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Draxin antibodies...
Previous: Septin9
Next: Inf2
Draxin Infographic by Boster Bio
All Draxin Products
Product
Figures
Specificity
Applications
Price
Draxin Overview
Facts about Draxin.
Draxin
Chemorepulsive axon guidance protein needed for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development.
Willing to neutralize or neutralize neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) through its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Draxin |
| Uniprot: | Q6PAL1 |
| Entrez: | 70433 |
Family
| Belongs to: |
|---|
| draxin family |
Alternative Names
AGPA3119; C1orf187; chromosome 1 open reading frame 187; dorsal inhibitory axon guidance protein; Dorsal repulsive axon guidance protein; Draxin; FLJ34999; MGC117222; Neucrin; UNQ3119
Molecular Weight
Mass (kDA):
38.363 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 4|4 E2 |
| Sequence: | 4; |
Tissue Specificity
Predominantly expressed in developing neural tissues. Expressed in many brain regions, including the olfactory bulb, cortex, midbrain, cerebellum and pontine nuclei in postnatal day 0 (P0). Detected in the dorsal spinal cord and commissural axons. In the forebrain commissures, it is expressed in the regions that surround the corpus callosum, hippocampal commissure, and anterior commissure, such as the midline glial cells, indusium griseum glia, and glial wedge.
Diseases
- Nervousness
- Congenital Absence
- Malignant Neoplasms
- Down Syndrome
- Tissue Adhesions
- Colorectal Cancer
- Agenesis Of Corpus Callosum
Pathways
- Axon Guidance
- Cell Adhesion
- Cell Division
- Cell Migration
- Cell Proliferation
- Neural Crest Cell Migration
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Draxin
bosterbio.com/bosterbio-gene-info-cards/Draxin
References
PMID: 19857465 by Miyake A., et al. Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling.
PMID: 19150847 by Islam S.M., et al. Draxin, a repulsive guidance protein for spinal cord and forebrain commissures.