This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Dedicator of cytokinesis protein 2.
May also take part in IL2 transcriptional activation via the activation of RAC2. .
Human | |
---|---|
Gene Name: | DOCK2 |
Uniprot: | Q92608 |
Entrez: | 1794 |
Belongs to: |
---|
DOCK family |
dedicator of cytokinesis 2; dedicator of cytokinesis protein 2; DOCK2; FLJ46592; KIAA0209dedicator of cyto-kinesis 2
Mass (kDA):
211.948 kDA
Human | |
---|---|
Location: | 5q35.1 |
Sequence: | 5; NC_000005.10 (169637247..170083382) |
Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon.
Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Colocalizes with F-actin.
PMID: 10559471 by Nishihara H., et al. Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins.
PMID: 12393632 by Nishihara H., et al. DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines.