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Docking protein 1 Antibodies
AND DOK1 ELISA kits, Docking protein 1 Proteins
Many biological assays use antibodies to detect Docking protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Docking protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Docking protein 1 antibodies...
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DOK1 Infographic by Boster Bio
All DOK1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1429
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1429
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2385
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2385
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2386
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2386
1 kit, containing two 96-well plates and all necessary reagents
DOK1 Overview
Facts about Docking protein 1.
Docking protein 1 (DOK1)
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They supply a docking platform for the assembly of multimolecular signaling complexes.
DOK1 seems to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Gene Information
| Human | |
|---|---|
| Gene Name: | DOK1 |
| Uniprot: | Q99704 |
| Entrez: | 1796 |
Family
| Belongs to: |
|---|
| DOK family |
Alternative Names
docking protein 1 (downstream of tyrosine kinase 1); docking protein 1; docking protein 1, 62kD (downstream of tyrosine kinase 1); docking protein 1, 62kDa (downstream of tyrosine kinase 1); Downstream of tyrosine kinase 1; MGC117395; MGC138860; p62(dok); P62DOK; pp62
Molecular Weight
Mass (kDA):
52.392 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p13.1 |
| Sequence: | 2; NC_000002.12 (74549020..74557551) |
Tissue Specificity
Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.
Subcellular Localizations
[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm, perinuclear region.
Diseases
- Neoplasms
- Leukemia
- Malignant Neoplasms
- Tissue Adhesions
- Myeloid Leukemia, Chronic
- Myeloid Leukemia
- Cell Transformation, Neoplastic
- Metaplastic Cell Transformation
- Lymphoid Leukemia
- Nervousness
- Chronic Lymphocytic Leukemia
- Autoimmunity
- Burkitt Lymphoma
Interacting Proteins
- Cbll1
- ERBB2
- SRMS
Pathways
- Cell Proliferation
- Localization
- Cell Activation
- Cell Migration
- Mitosis
- Cell Adhesion
- Pathogenesis
- Methylation
- Cytokine Production
- Secretion
- T Cell Activation
- Cell Motility
- Dna Methylation
PTMs
- Phosphorylation
- Methylation
- Acetylation
Research Areas
- Phospho-Specific
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DOK1
bosterbio.com/bosterbio-gene-info-cards/DOK1
References
PMID: 9008160 by Carpino N., et al. p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells.
PMID: 10940083 by Hubert P., et al. Molecular cloning of a truncated p62Dok1 isoform, p22Dokdel.
1 Publications of Boster Docking protein 1 Antibodies & ELISA Kits
- PubMed ID: 10.1096/fj.201801949RR, Talin promotes integrin activation accompanied by generation of tension in talin...
*More publications can be found for each product on its corresponding product page