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Dynactin subunit 1 Antibodies
AND DCTN1 ELISA kits, Dynactin subunit 1 Proteins
Many biological assays use antibodies to detect Dynactin subunit 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dynactin subunit 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dynactin subunit 1 antibodies...
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DCTN1 Infographic by Boster Bio
All DCTN1 Products
Product
Figures
Specificity
Applications
Price
Bovine, Human, Mouse, Swine
IF, WB
$380
Cat # M02175-1
100ul
Cat # M02175-1
100ul
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02175-2
100 μg/vial
Cat # A02175-2
100 μg/vial
DCTN1 Overview
Facts about Dynactin subunit 1.
Dynactin subunit 1 (DCTN1)
Plays a crucial role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruitment and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein.
Critical for targeting dynein to microtubule plus ends, recruitment dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the trail ). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702).
Gene Information
| Human | |
|---|---|
| Gene Name: | DCTN1 |
| Uniprot: | Q14203 |
| Entrez: | 1639 |
Family
| Belongs to: |
|---|
| dynactin 150 kDa subunit family |
Alternative Names
DAP-150; DCTN1; DP-150; dynactin 1 (p150, Glued (Drosophila) homolog); Dynactin 1; Dynactin Subunit 1; glued homolog, Drosophila); HMN7B; p135; p150 Glued (Drosophila) homolog; p150-glued
Molecular Weight
Mass (kDA):
141.695 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p13.1 |
| Sequence: | 2; NC_000002.12 (74361154..74392087, complement) |
Tissue Specificity
Brain.
Subcellular Localizations
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Nucleus envelope. Cytoplasm, cell cortex. Localizes to microtubule plus ends (PubMed:17828277, PubMed:22777741, PubMed:25774020). Localizes preferentially to the ends of tyrosinated microtubules (PubMed:26972003). Localization at centrosome is regulated by SLK-dependent phosphorylation (PubMed:23985322). Localizes to centrosome in a PARKDA-dependent manner (PubMed:20719959). Local
Diseases
- Amyotrophic Lateral Sclerosis
- Sclerosis
- Primary Lateral Sclerosis
- Motor Neuron Disease
- Nerve Degeneration
- Dementia
- Neurodegenerative Disorders
- Secondary Parkinson Disease
- Hypoventilation
- Atrophy
- Dystrophy
- Depressive Disorder
Interacting Proteins
- ACTR1B
- BBS4
- Hap1
- MAPRE1
- SNX6
Pathways
- Transport
- Pathogenesis
- Localization
- Cell Death
- Vesicle Transport
- Autophagic Cell Death
- Mitosis
- Skin Development
- Oocyte Maturation
- Muscle Atrophy
PTMs
- Phosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DCTN1
bosterbio.com/bosterbio-gene-info-cards/DCTN1
References
PMID: 9799602 by Collin G.B., et al. Human DCTN1: genomic structure and evaluation as a candidate for Alstrom syndrome.
PMID: 8838327 by Holzbaur E.L.F., et al. Localization of the DCTN1 gene encoding p150Glued to human chromosome 2p13 by fluorescence in situ hybridization.