CD276 antigen (CD276)

May participate in the regulation of T-cell-mediated immune reaction. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis in addition to a part of marker for detection of neuroblastoma cells.

May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic action at mucosal surfaces. Could also play a key role in supplying the placenta and fetus with a suitable immunological environment throughout pregnancy.