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Cytochrome P450 26B1 Antibodies
AND CYP26B1 ELISA kits, Cytochrome P450 26B1 Proteins
Many biological assays use antibodies to detect Cytochrome P450 26B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 26B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 26B1 antibodies...
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CYP26B1 Infographic by Boster Bio
All CYP26B1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$523
Cat # M02691
100 µl
Cat # M02691
100 µl
Human
$628
Cat # LS056603
100 µg
Cat # LS056603
100 µg
CYP26B1 Overview
Facts about Cytochrome P450 26B1.
Cytochrome P450 26B1 (CYP26B1)
Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a taste for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA.
Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH- RA. Essential for postnatal survival.
Gene Information
| Human | |
|---|---|
| Gene Name: | CYP26B1 |
| Uniprot: | Q9NR63 |
| Entrez: | 56603 |
Family
| Belongs to: |
|---|
| cytochrome P450 family |
Alternative Names
CYP26A2; Cytochrome P450 26A2; cytochrome P450 26B1; cytochrome P450 CYP26B1 variant 2; Cytochrome P450 retinoic acid-inactivating 2; cytochrome P450 retinoid metabolizing protein; cytochrome P450, family 26, subfamily B, polypeptide 1; Cytochrome P450RAI-2; DKFZp686G0638; EC 1.14; MGC129613; P450RAI2; P450RAI-2; Retinoic acid-metabolizing cytochrome
Molecular Weight
Mass (kDA):
57.513 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p13.2 |
| Sequence: | 2; NC_000002.12 (72129238..72147862, complement) |
Tissue Specificity
Highly expressed in brain, particularly in the cerebellum and pons.
Subcellular Localizations
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Diseases
- Malignant Neoplasms
- Teratogenic Effect
- Carcinoma
- Vitamin A Deficiency
- Congenital Abnormality
- Crest Syndrome
- Limb Defect
- Hypoplasia
- Inflammation
- Nervousness
- Neoplasms
- Refractory Anemia With Ringed Sideroblasts
- Spina Bifida
Pathways
- Meiosis
- Cell Proliferation
- Cell Differentiation
- Localization
- Sex Determination
- Spermatogenesis
- Limb Development
- Oogenesis
- Pathogenesis
- Cell Death
- Lung Development
- Germ Cell Development
- Fertilization
PTMs
- Methylation
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP26B1
bosterbio.com/bosterbio-gene-info-cards/CYP26B1
References
PMID: 10823918 by White J.A., et al. Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism.
PMID: 22019272 by Laue K., et al. Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid.