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Catenin delta-1 Antibodies
AND CTNND1 ELISA kits, Catenin delta-1 Proteins
Many biological assays use antibodies to detect Catenin delta-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Catenin delta-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Catenin delta-1 antibodies...
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CTNND1 Infographic by Boster Bio
All CTNND1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC, WB
$360
Cat # P02333
100 µl
Cat # P02333
100 µl
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M02333
100 μl
Cat # M02333
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1093
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1093
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2243
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2243
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A02333Y228-1
100ul
Cat # A02333Y228-1
100ul
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02333-3
100 μg/vial
Cat # A02333-3
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A02333-4
100 μg/vial
Cat # A02333-4
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M02333-2
100 μg/vial
Cat # M02333-2
100 μg/vial
Human, Mouse, Rat
IHC, WB
$370
Cat # M02333Y228
100 µl/vial
Cat # M02333Y228
100 µl/vial
CTNND1 Overview
Facts about Catenin delta-1.
Catenin delta-1 (CTNND1)
Binds to and inhibits the transcriptional repressor ZBTB33, which might lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and modulates the cell adhesion properties of both C-, E- and N-cadherins, being crucial for their surface stability.
Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
Gene Information
| Human | |
|---|---|
| Gene Name: | CTNND1 |
| Uniprot: | O60716 |
| Entrez: | 1500 |
Family
| Belongs to: |
|---|
| beta-catenin family |
Alternative Names
Cadherin-associated Src substrate; CAS; catenin (cadherin-associated protein), delta 1; catenin delta-1; CTNND; KIAA0384P120CAS; p120 catenin; p120; p120(CAS); p120(CTN); p120cas; p120ctn
Molecular Weight
Mass (kDA):
108.17 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q12.1 |
| Sequence: | 11; NC_000011.10 (57761802..57819540) |
Tissue Specificity
Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.
Subcellular Localizations
Cell junction, adherens junction. Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts (PubMed:15240885, PubMed:17047063). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (PubMed:17047063). CDH1 enhances cell membrane localization (PubMed:15240885). Isoforms 4A and 1AB are excluded from the nucleus (PubMed:11896187).; [Isoform 1A]: Nucleus.; [Isoform 2A]: Nucleus.; [Isoform 3A]: Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Malignant Neoplasm Of Lung
- Lung Neoplasms
- Non-small Cell Lung Carcinoma
- Adult Acute Lymphocytic Leukemia
- Metastatic Malignant Neoplasm To The Lymph Node
- Uterine Cervical Neoplasm
- Hypoxia
- Malignant Tumor Of Cervix
- Carcinogenesis
- Carcinoma, Neuroendocrine
Interacting Proteins
- Cdh1
- EGFR
- FRMD5
- KCTD6
- NANOS1
- PLEKHA7
- PLPP3
- PTPRJ
Pathways
- Localization
- Transport
- Actin Cytoskeleton Organization
- Cell Migration
- Vesicle Transport
- Aging
- Fertilization
- Oocyte Maturation
- Cytoskeleton Organization
- Regulation Of Actin Cytoskeleton Organization
- System Development
- Cell Death
PTMs
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CTNND1
bosterbio.com/bosterbio-gene-info-cards/CTNND1
References
PMID: 9653641 by Keirsebilck A., et al. Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms.
PMID: 7623846 by Kim L., et al. The cytoplasmic tyrosine kinase FER is associated with the catenin- like substrate pp120 and is activated by growth factors.