CREB3L3 Antibodies

AND CREB3L3 ELISA kits, CREB3L3 Proteins

Many biological assays use antibodies to detect CREB3L3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CREB3L3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CREB3L3 antibodies...

We validate the specificity of these antibodies to CREB3L3 by testing them on tissues known to express CREB3L3 positively and negatively. Browse below to find the CREB3L3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CREB3L3 Infographic by Boster Bio

All CREB3L3 Products

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Anti-CR3L3 CREB3L3 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A05611
100ul

CREB3L3 (NM_032607) Human Over-expression Lysate

Human

$628
Cat # LS084699
100 µg

CREB3L3 Overview

Facts about Cyclic AMP-responsive element-binding protein 3-like protein 3.

CREB3L3 3D structure. Source: alphafold

Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3)

Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation.

In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B component.

Gene Information

Human
Gene Name:	CREB3L3
Uniprot:	Q68CJ9
Entrez:	84699

Family

Belongs to:

bZIP family

Alternative Names

cAMP responsive element binding protein 3-like 3; cAMP-responsive element-binding protein 3-like protein 3; CREB/ATF family transcription factor; CREB-H; CREBHMGC126557; cyclic AMP-responsive element-binding protein 3-like protein 3; MGC126553; Transcription factor CREB-H

Molecular Weight

Mass (kDA):
49.077 kDA

Genomic Context


Human

Location:	19p13.3
Sequence:	19; NC_000019.10 (4153631..4173054)

Tissue Specificity

Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Processed cyclic AMP-responsive element-binding protein 3-like protein 3]: Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.

Diseases

Inflammation
Obesity
Endoplasmic Reticulum Stress
Chimera Disorder
Fatty Liver
Physiological Stress
Metabolic Diseases
Malignant Neoplasm Of Liver
Inflammatory Response
Sarcoma
Carcinoma
Insulin Resistance
Nonalcoholic Steatohepatitis

Feline Urological Syndrome
Patient Dependence On
Malignant Neoplasms
Low Grade Fibromyxoid Sarcoma
Anemia
Liver Carcinoma
Steatohepatitis

Interacting Proteins

ATF6
CREB3
NFIL3

Pathways

Transport
Proteolysis
Glycosylation
Gluconeogenesis
Acute Inflammatory Response
Golgi Localization
Osteoblast Differentiation
Hepatocyte Differentiation
Localization
Sterol Homeostasis
Inflammatory Response

Nuclear Transport
Glucose Homeostasis
Lipid Homeostasis
Fatty Acid Oxidation
Lipid Transport

PTMs

Cleavage
Glycosylation

Deglycosylation
Phosphorylation

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CREB3L3

References

PMID: 11353085 by Omori Y., et al. CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver- specific expression.

PMID: 15221005 by Yamada S., et al. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.