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- Table of Contents
Facts about Cbp/p300-interacting transactivator 4.
Acts as transcriptional coactivator for TFAP2/AP-2.
Improves estrogen-dependent transactivation mediated by estrogen receptors.May be an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.
Mouse | |
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Gene Name: | Cited4 |
Uniprot: | Q9WUL8 |
Entrez: | 56222 |
Belongs to: |
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CITED family |
cbp/p300-interacting transactivator 4; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain4,MRG-2; MRG2; MSG1-related protein 2; transcriptional co-activator 4
Mass (kDA):
18.398 kDA
Mouse | |
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Location: | 4 D2.2|4 56.52 cM |
Sequence: | 4; |
Strongly expressed in heart, spleen and testis, and weakly in liver and kidney.
PMID: 12504852 by Yahata T., et al. Cloning of mouse Cited4, a member of the CITED family p300/CBP- binding transcriptional coactivators: induced expression in mammary epithelial cells.
PMID: 11581164 by Yahata T., et al. Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein.