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CEP72 Antibodies
AND CEP72 ELISA kits, CEP72 Proteins
Many biological assays use antibodies to detect CEP72, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CEP72 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CEP72 antibodies...
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CEP72 Overview
Facts about Centrosomal protein of 72 kDa.
Centrosomal protein of 72 kDa (CEP72)
Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is necessary for proper tension generation between sister chromatids.
Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication.
Gene Information
| Human | |
|---|---|
| Gene Name: | CEP72 |
| Uniprot: | Q9P209 |
| Entrez: | 55722 |
Family
| Belongs to: |
|---|
| CEP72 family |
Alternative Names
centrosomal protein 72kDa; centrosomal protein of 72 kDa; Cep72; KIAA1519FLJ10565; MGC5307
Molecular Weight
Mass (kDA):
71.718 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5p15.33 |
| Sequence: | 5; NC_000005.10 (612340..668744) |
Subcellular Localizations
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner.
Diseases
- Arthritis
- Lung Neoplasms
- Malignant Neoplasms
- Autoimmune Reaction
- Non-small Cell Lung Carcinoma
- Neoplasms
- Rheumatoid Arthritis
Interacting Proteins
- ATXN7
- CATIP
- CDK5RAP2
- FAM90A1
- KIZ
- LNX1
- NME7
- PCM1
- PIN4
- PSMA1
Pathways
- Localization
- Microtubule Nucleation
- Mitosis
- Pathogenesis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CEP72
bosterbio.com/bosterbio-gene-info-cards/CEP72
References
PMID: 19536135 by Oshimori N., et al. Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation.
PMID: 26297806 by Kodani A., et al. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication.