Nucleosome-remodeling factor subunit BPTF (BPTF)

Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on'Lys-4' (H3K4me3), which mark transcription start sites of virtually all genes that are active.

May also regulate transcription via direct binding to DNA or transcription factors. .