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- Table of Contents
Facts about Nucleosome-remodeling factor subunit BPTF.
May also regulate transcription via direct binding to DNA or transcription factors. .
Human | |
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Gene Name: | BPTF |
Uniprot: | Q12830 |
Entrez: | 2186 |
Belongs to: |
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PBTF family |
bromodomain and PHD domain transcription factor; Bromodomain and PHD finger-containing transcription factor; bromodomain PHD finger transcription factor; EC 3.6.1; EC 6.2.1.5; FAC1fetal Alz-50 reactive clone 1; FALZnucleosome-remodeling factor subunit BPTF; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigennucleosome remodeling factor, large subunit; NURF301
Mass (kDA):
338.262 kDA
Human | |
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Location: | 17q24.2 |
Sequence: | 17; NC_000017.11 (67825503..67984378) |
Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).
Cytoplasm. Nucleus. In brains of Alzheimer disease patients, present in a subset of amyloid-containing plaques.
PMID: 10662542 by Jones M.H., et al. Identification and characterization of BPTF, a novel bromodomain transcription factor.
PMID: 7621746 by Bowser R., et al. FAC1, a novel gene identified with the monoclonal antibody Alz50, is developmentally regulated in human brain.