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BAG1 Antibodies
AND BAG1 ELISA kits, BAG1 Proteins
Many biological assays use antibodies to detect BAG1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BAG1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BAG1 antibodies...
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BAG1 Infographic by Boster Bio
All BAG1 Products
Product
Figures
Specificity
Applications
Price
Anti-Bag1 Antibody Picoband®
2 Citations 1 Q&As
Human, Mouse, Rat
IHC, WB
$370
Cat # A02423-2
100 μg/vial
Cat # A02423-2
100 μg/vial
Anti-BAG-1L Rabbit Monoclonal Antibody, Clone#RM310
1 Citations 5 Q&As
Human
IHC, ICC, WB
$506
Cat # M02423
100uL
Cat # M02423
100uL
Human
IHC, WB
$431
Cat # M02423-1
100uL
Cat # M02423-1
100uL
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M02423-2
100 μl/vial
Cat # M02423-2
100 μl/vial
BAG1 Overview
Facts about BAG family molecular chaperone regulator 1.
BAG family molecular chaperone regulator 1 (BAG1)
Co-chaperone for HSP70 and HSC70 chaperone proteins.
Acts as a nucleotide-exchange variable (NEF) promoting the release of ADP in the HSP70 and HSC70 proteins thereby triggering client/substrate protein release.Nucleotide release is mediated through its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated through its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and contains anti-apoptotic action (PubMed:12724406).
Gene Information
| Human | |
|---|---|
| Gene Name: | BAG1 |
| Uniprot: | Q99933 |
| Entrez: | 573 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BAG family molecular chaperone regulator 1; Bag1; Bag-1; Bcl-2 associating athanogene-1 protein; Bcl-2-associated athanogene 1; BCL2-associated athanogene; Bcl-2-binding protein; glucocortoid receptor-associated protein RAP46,46-KD; HAP; RAP46
Molecular Weight
Mass (kDA):
38.779 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p13.3 |
| Sequence: | 9; NC_000009.12 (33252471..33264708, complement) |
Tissue Specificity
Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level).
Subcellular Localizations
[Isoform 1]: Nucleus. Cytoplasm. Isoform 1 localizes predominantly to the nucleus.; [Isoform 2]: Cytoplasm. Nucleus. Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock.; [Isoform 4]: Cytoplasm. Nucleus. Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic s
Diseases
- Malignant Neoplasms
- Neoplasms
- Toxoplasmosis
- Toxoplasmosis, Animal
- Malignant Neoplasm Of Breast
- Carcinoma
- Nervousness
- Mammary Neoplasms
- Infective Disorder
- Muscle Twitch
- Nerve Degeneration
- Neoplasm Metastasis
Interacting Proteins
- HSPA8
- PSMD2
- STUB1
- TRIM23
- TRIM27
Pathways
- Innervation
- Localization
- Cell Death
- Pathogenesis
- Cell Cycle
- Aging
- Immune Response
- Cell Proliferation
- Regeneration
- Protein Folding
- Cell Growth
- Transport
- Programmed Cell Death
PTMs
- Phosphorylation
- Ubiquitination
Research Areas
- Apoptosis
- Cancer
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BAG1
bosterbio.com/bosterbio-gene-info-cards/BAG1
References
PMID: 8524784 by Zeiner M., et al. A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning.
PMID: 8812483 by Takayama S., et al. Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12.
2 Publications of Boster BAG1 Antibodies & ELISA Kits
- PubMed ID: 10.3748/wjg.v13.i28.3883, Clinicopathologic significance of BAG1 and TIMP3 expression in colon carcinoma
- PubMed ID: 17657847, Bai Yx, Yi Jl, Li Jf, Sui H. World J Gastroenterol. 2007 Jul 28;13(28):3883-5. C...
*More publications can be found for each product on its corresponding product page