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, No Gclids
ARL3 Antibodies
AND ARL3 ELISA kits, ARL3 Proteins
Many biological assays use antibodies to detect ARL3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARL3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARL3 antibodies...
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ARL3 Infographic by Boster Bio
All ARL3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M04080
100 µl
Cat # M04080
100 µl
ARL3 Overview
Facts about ADP-ribosylation factor-like protein 3.
ADP-ribosylation factor-like protein 3 (ARL3)
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the speed of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP) (PubMed:16525022, PubMed:18588884). Required for normal cytokinesis and cilia signaling (PubMed:22085962).
Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins like NPHP3 into the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter to the cilium (PubMed:22085962).
Gene Information
| Human | |
|---|---|
| Gene Name: | ARL3 |
| Uniprot: | P36405 |
| Entrez: | 403 |
Family
| Belongs to: |
|---|
| small GTPase superfamily |
Alternative Names
ADP-ribosylation factor-like 3; ARFL3ADP-ribosylation factor-like protein 3; ARF-like 3
Molecular Weight
Mass (kDA):
20.456 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q24.32 |
| Sequence: | 10; NC_000010.11 (102673731..102714397, complement) |
Tissue Specificity
Expressed in the retina. Strongly expressed in connecting cilium, the myoid region of the inner segments (IS) and in cone photoreceptors (at protein level).
Subcellular Localizations
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium. Detected predominantly in the photoreceptor connecting cilium. Present on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules.
Diseases
- Retinitis Pigmentosa
- Retinal Degeneration
- Bardet-biedl Syndrome
- Degenerative Disorder
- Familial Aplasia Of The Vermis
- Dysplasia
- Patient Dependence On
- Neoplasms
- Cytoplasmic Accumulation
- Meckel-gruber Syndrome
- Abnormal Degeneration
Interacting Proteins
- PDE6D
- UNC119
Pathways
- Transport
- Localization
- Golgi Localization
- Secretion
- Cell Adhesion
- M Phase
- Cell Cycle Arrest
- Cytokinesis
- Microtubule Depolymerization
- Cell Cycle
- Lipid Binding
- Phototransduction
- Intraflagellar Transport
PTMs
- Ribosylation
- Prenylation
- Acetylation
- Myristoylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARL3
bosterbio.com/bosterbio-gene-info-cards/ARL3
References
PMID: 8034651 by Cavenagh M.A., et al. ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues.
PMID: 10831612 by Bhamidipati A., et al. ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.