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ARNT Antibodies
AND ARNT ELISA kits, ARNT Proteins
Many biological assays use antibodies to detect ARNT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARNT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARNT antibodies...
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ARNT Infographic by Boster Bio
All ARNT Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1699
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1699
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M02263-2
100 µl
Cat # M02263-2
100 µl
ARNT Overview
Facts about Aryl hydrocarbon receptor nuclear translocator.
Aryl hydrocarbon receptor nuclear translocator (ARNT)
Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding.
The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | ARNT |
| Uniprot: | P27540 |
| Entrez: | 405 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ARNT protein; ARNT; aryl hydrocarbon receptor nuclear translocator; BHLHE2; HIF1 beta; HIF-1 beta; HIF1B; HIF1BETA; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1, beta subunit; Hypoxia-inducible factor 1-beta; nuclear translocator; TANGO
Molecular Weight
Mass (kDA):
86.636 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q21.3 |
| Sequence: | 1; NC_000001.11 (150809713..150876737, complement) |
Subcellular Localizations
Nucleus.
Diseases
- Hypoxia
- Malignant Neoplasms
- Neoplasms
- Liver Carcinoma
- Tumor Angiogenesis
- Anoxia
- Malignant Neoplasm Of Breast
- Carcinoma
- Pathologic Neovascularization
- Mammary Neoplasms
- Liver Neoplasms, Experimental
- Von Hippel-lindau Syndrome
Interacting Proteins
- AHR
- EPAS1
- HIF1A
- NCOA7
- NCOR2
Pathways
- Angiogenesis
- Localization
- Response To Hypoxia
- Cell Growth
- Cell Proliferation
- Translation
- Secretion
- Oxygen Homeostasis
- Cell Cycle
- Pathogenesis
- Glycolysis
- Transport
- Cell Death
PTMs
- Phosphorylation
- Hydroxylation
- Ubiquitination
- Methylation
- Oxidation
- Cleavage
- Dephosphorylation
Research Areas
- Angiogenesis
- Autophagy
- Cancer
- Cellular Markers
- Chromatin Research
- HIF Target Genes
- Hypoxia
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARNT
bosterbio.com/bosterbio-gene-info-cards/ARNT
References
PMID: 1852076 by Hoffman E.C., et al. Cloning of a factor required for activity of the Ah (dioxin) receptor.
PMID: 7539918 by Wang G.L., et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.