Arginase-2, mitochondrial Antibodies

Arginase-2, mitochondrial (ARG2)

Extrahepatic arginase functions to modulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is an essential regulator of innate and adaptive immune responses.

Appears to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970). May contribute to the immune evasion of H.

Gene Information

Human
Gene Name:	ARG2
Uniprot:	P78540
Entrez:	384

Family

Belongs to:
arginase family

Alternative Names

ARG2; Arginase 2; arginase, type II; Arginase-2; arginase-2, mitochondrial; EC 3.5.3; EC 3.5.3.1; kidney arginase; Kidney-type arginase; L-arginine amidinohydrolase; L-arginine ureahydrolase; nonhepatic arginase; Non-hepatic arginase; Type II Arginase

Molecular Weight

Mass (kDA):
38.578 kDA

Genomic Context

Human
Location:	14q24.1
Sequence:	14; NC_000014.9 (67619920..67651708)

Tissue Specificity

Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas. Expressed in activated T cells (PubMed:27745970).

Subcellular Localizations

Mitochondrion.

Diseases

• Neoplasms
• Malignant Neoplasms
• Inflammation
• Asthma
• Carcinoma
• Cell Transformation, Neoplastic
• Disease Of Adrenal Medulla
• Inflammatory Response
• Hyperargininemia
• Hypertensive Disease
• Thyroid Neoplasm
• Diabetes Mellitus
• Spondylarthropathies

• Malignant Paraganglionic Neoplasm
• Malignant Neoplasm Of Thyroid
• Bronchial Hyperreactivity
• Shwachman Syndrome
• Obesity
• Adenoma
• Follicular Thyroid Carcinoma

Pathways

• Transport
• Immune Response
• Urea Cycle
• Inflammatory Response
• Methylation
• Pathogenesis
• Translation
• Cell Proliferation
• Proteolysis
• Wound Healing
• Localization
• Mating
• Oncogenesis

• Protein Transport
• Aging
• Arginine Transport
• Cell Death
• Secretion
• Cell Activation
• Protein Targeting

PTMs

• Methylation
• Phosphorylation
• Deamination
• Acetylation
• Oxidation
• Cleavage
• Sumoylation

• Sulphation
• Carboxylation
• Nitrosylation
• Amidation
• Citrullination
• Nitration
• Reduction

• Myristoylation

Research Areas

• Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARG2

The Best Uses Of The ARG2 Marker From Boster Bio

If you're in search of an effective marker for arginine metabolism you've come to the right place. Boster Bio's Arginine Metabolis Marker has numerous advantages. This article will focus on the specificity, simplicity of use and low background of Boster Bio's ARG2 Marker. This product is highly specific and has been used by scientists from all over the world.

Boster Bio's Arginine Metaabolism Marker

Arginine is an amino acid that has multiple functions that is found in animal cells. It is a precursor for various amino acids that are important, including proline, glutamate, nitric oxide, and urea. Arginine metabolism is the expression of arginases, enzymes, which also produce ornithine as well as the urea. Proline is required for collagen synthesis, while urea is crucial for the breakdown of proteins and detoxification. Arginase II and arginine descarboxylase are two rate-controlling enzymes involved in the metabolism of arginine.

The metabolism of arginine is controlled by the y+ system of amino acid transporters that are cationic and by enzymes responsible for catabolism. Intracellular arginine metabolism is controlled by arginine amidinotransferase as well as the nitric oxide synthase.

Its uniqueness

Find the right source if are in search of an ARG2 antibody. Boster Bio provides antibodies that react with mouse and human samples. The antibodies can be stored at -20 degrees C or freeze them for up to six months. ARG2 is one of the genes found in the brain. Here are some of the uses for this marker. This protein is vital in the development of brain tumors, immune-mediated disorders, and aging.

Its simplicity of use

It is essential to design user-friendly products. It refers to the ease of using tools and products for everyday use. Examples of easy-to-use products include wheelchair-accessible designs and software with one-screen configuration. Other examples include apps with intuitive interfaces. This article will discuss the various elements of ease of use and how to measure their effectiveness. It isn't a good idea to want users to be wasting their time with a program or product that does not work properly for them.

Context gives designers constraints. It is the frame for all user experiences, offering them a guide to approach the problem. Keeping context in mind will help you comprehend the expectations of mobile and desktop users. Also, you'll know how to design a product service that is a hit with everyone. A good design is easy to use regardless of the platform. The first step is to determine the context of the product or service that you're developing.

Its soft background

The ARG2 marker is not able to distinguish the type of cell it is. It is found in T cells. The expression levels of Arg2 are low in these cells. This background is low, which makes it suitable for a wide range of experiments, such as the qPCR. This kind of test has its drawbacks. Because the background is low the need for many studies to confirm the results.