Anillin Antibodies

Anillin (ANLN)

Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression.

Plays a role in bleb assembly through metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636).

Gene Information

Human
Gene Name:	ANLN
Uniprot:	Q9NQW6
Entrez:	54443

Family

Belongs to:
No superfamily

Alternative Names

actin-binding protein anillin; anillin (Drosophila Scraps homolog), actin binding protein; ANILLIN; anillin, actin binding protein (scraps homolog, Drosophila); anillin, actin binding protein; DKFZp779A055; Drosophila Scraps homolog; scra; Scraps

Molecular Weight

Mass (kDA):
124.199 kDA

Genomic Context

Human
Location:	7p14.2
Sequence:	7; NC_000007.14 (36389809..36453791)

Tissue Specificity

Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.

Subcellular Localizations

Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cell projection, bleb. Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.

Diseases

• Malignant Neoplasms
• Malignant Neoplasm Of Lung
• Carcinoma
• Neoplasms
• Adenocarcinoma
• Malignant Squamous Cell Neoplasm
• Lung Neoplasms
• Non-small Cell Lung Carcinoma
• Neoplasm Metastasis
• Neoplasm Invasiveness
• Cell Invasion
• Adenocarcinoma Of Lung (disorder)

• Learning Disorders
• Exposure To Ionizing Radiation
• Neurodegenerative Disorders
• Malignant Neoplasm Of Breast
• Head And Neck Carcinoma
• Carcinogenesis
• Pancreatitis

Pathways

• Cell Proliferation
• Cell-cell Signaling
• Reverse Transcription
• System Development
• Nervous System Development
• Cell Differentiation
• Immune Response

• Cell Growth
• Localization

PTMs

• Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ANLN

Boster Bio - Best Uses of the ANLN Marker

In this article, I'm going to review Boster Bio: Anti-Anillin/ANLN Marker and the Anti-KHDRBS2 as well as Anti-Bax (S4) Antibodies. These antibodies should prove useful in your research. They are available in a variety of drugstores as well as online stores. Boster's aim in research on antibodies is to make it easier for researchers. Boster's products have been validated across multiple platforms, including positive and negative samples. Boster also rewards early reviewers of products with product credits. These rewards are offered to scientists from all over the world.

Boster Bio: Anti Anillin/ANLN Marker

The ANLN marker is a typical molecule that is present in blood of humans. It is used to identify tumors, inflammation and other illnesses. It is a marker that has multiple uses. Researchers use it to detect a number of biomarkers in research. Boster biotech manufactures several antibodies as well as an ELISA kit to accomplish this. These antibodies are sensitive enough that they can detect molecules of interest at a picogram scale. Boster Bio: The Most Effective Uses of ANLN Marker

The ANLN marker has been studied extensively in various fields of science. The Boster bio Anti-Anillin/ANLN is part of their Picoband(tm) catalog. This antibody is able to react with Human, Mouse, Rat, and Rat. It is also highly cross-reactive with other proteins. It is particularly useful in Flow Cytometry. It can also be utilized in Western Blot (WB) applications.

In an investigation, ANLN protein expression was detected in two cell lines, SKBR3 and T47D, which are both breast cancer cells. SKBR3 cells lack of ER expression, while T47D cells express ER. The cells were cultivated in McCoy's medium and RPMI-1640, respectively. Both cells were tested for Mycoplasma contamination, which makes ANLN an excellent choice for research in area of cancer biology.

Boster Bio: Anti-KHDRBS2 Antibody

Boster Bio is the ideal place to locate an ANLN antigen of high-quality for your next research. This ANLN antibody has been validated for use with Western Blot and Flow Cytometry in human and mouse samples. It has been recognized by scientists all over the world. Learn more about Boster's ANLN antibody here. We hope you enjoy it!

Boster Bio Anti-Bax Antibody S4

The ANLN Marker is a specialized protein used in immunohistochemistry. While it has been around for a long time however, its many applications in cell biology were only discovered in the last few years. The company, which has various other products, offers anti-ki67 antibody. These monoclonal antibodies can be used to identify and specifically target the ANLN protein. They can be utilized in a variety applications like immunohistochemistry, western blotting, or immunohistochemistry.

This anti-human protein has been used for many years to detect cancerous cells. It is also known by the HTATIP or BRCA1 gene. It is also used to identify many other types of cancer such as those with mutated BRCA1 or HTATIP. Other protein antigens used in cancer research include IDh2, PARP10, and YAP1.

ANLN has been examined in breast cancer cells. The ANLN protein is found in normal and malignant breast tissues. SKBR3 cells are ER negative, whereas T47D cells show ER expression. Both cell lines were maintained in 5% CO2 at 37°C and were confirmed to be free of Mycoplasma contamination. The results of these research studies support the idea that ANLN may have a prognostic significance in breast cancer.