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, No Gclids
Anillin Antibodies
AND ANLN ELISA kits, Anillin Proteins
Many biological assays use antibodies to detect Anillin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Anillin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Anillin antibodies...
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ANLN Infographic by Boster Bio
All ANLN Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # A03997-1
100 μg/vial
Cat # A03997-1
100 μg/vial
ANLN Overview
Facts about Anillin.
Anillin (ANLN)
Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression.
Plays a role in bleb assembly through metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636).
Gene Information
| Human | |
|---|---|
| Gene Name: | ANLN |
| Uniprot: | Q9NQW6 |
| Entrez: | 54443 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
actin-binding protein anillin; anillin (Drosophila Scraps homolog), actin binding protein; ANILLIN; anillin, actin binding protein (scraps homolog, Drosophila); anillin, actin binding protein; DKFZp779A055; Drosophila Scraps homolog; scra; Scraps
Molecular Weight
Mass (kDA):
124.199 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p14.2 |
| Sequence: | 7; NC_000007.14 (36389809..36453791) |
Tissue Specificity
Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
Subcellular Localizations
Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cell projection, bleb. Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Lung
- Carcinoma
- Neoplasms
- Adenocarcinoma
- Malignant Squamous Cell Neoplasm
- Lung Neoplasms
- Non-small Cell Lung Carcinoma
- Neoplasm Metastasis
- Neoplasm Invasiveness
- Cell Invasion
- Adenocarcinoma Of Lung (disorder)
Pathways
- Cell Proliferation
- Cell-cell Signaling
- Reverse Transcription
- System Development
- Nervous System Development
- Cell Differentiation
- Immune Response
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ANLN
bosterbio.com/bosterbio-gene-info-cards/ANLN
References
PMID: 10931866 by Oegema K., et al. Functional analysis of a human homolog of the Drosophila actin binding protein anillin suggests a role in cytokinesis.
PMID: 12479805 by Kinoshita M., et al. Self- and actin-templated assembly of mammalian septins.