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, No Gclids
Ankyrin-2 Antibodies
AND ANK2 ELISA kits, Ankyrin-2 Proteins
Many biological assays use antibodies to detect Ankyrin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ankyrin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ankyrin-2 antibodies...
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ANK2 Overview
Facts about Ankyrin-2.
Ankyrin-2 (ANK2)
Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, such as cardiomyocytes, in addition to in striated muscle tissues. In skeletal muscle, required for proper localization of both DMD and DCTN4 and for the formation and/or equilibrium of a unique subset of microtubules associated with costameres and neuromuscular junctions.
In cardiomyocytes, required for coordinated assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors in sarcoplasmic reticulum/sarcolemma websites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction speed (PubMed:12571597).
Gene Information
| Human | |
|---|---|
| Gene Name: | ANK2 |
| Uniprot: | Q01484 |
| Entrez: | 287 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Ank2; Ankyrin 2 brain; Ankyrin 2; Ankyrin B; Ankyrin brain; Ankyrin nonerythroid; Brain Ankyrin
Molecular Weight
Mass (kDA):
433.715 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q25-q26 |
| Sequence: | 4; NC_000004.12 (112706018..113383740) |
Tissue Specificity
Present in plasma membrane of neurons as well as glial cells throughout the brain. Expressed in fetal brain and in temporal cortex of adult brain. Also expressed in the inner segments of rod photoreceptors in retina.
Subcellular Localizations
Cytoplasm, cytoskeleton. Membrane. Cytoplasm, myofibril, sarcomere, M line. Apical cell membrane. Cell membrane. Cell junction, synapse, postsynaptic cell membrane. Early endosome. Recycling endosome. Lysosome. Mitochondrion. Cytoplasm, myofibril, sarcomere, Z line. Cell membrane, sarcolemma, T-tubule. Expressed at the apical membrane of airway lung epithelial cells (By similarity). Localized to the plasma membrane of the inner segments of photoreceptors in retina. Colocalizes with SPTBN1 in a distinct intracellular compartment of neonatal cardiomyocytes (PubMed:19007774). In skeletal muscle,
Diseases
- Cardiac Arrhythmia
- Long Qt Syndrome
- Tissue Adhesions
- Sudden Death
- Sudden Cardiac Death
- Cardiac Death
- Tachycardia, Ventricular
- Torsades De Pointes
- Cardiovascular Diseases
- Sinus Node Dysfunction (disorder)
- Bradycardia
- Syncope
- Cardiac Fibrillation
Interacting Proteins
- CEP120
- EHD3
- GRB2
- KCNJ11
- SLC8A1
Pathways
- Localization
- Cell Adhesion
- Transport
- Membrane Organization
- Synapse Organization
- Insulin Secretion
- Protein Targeting
- Ion Transport
- Ossification
- Reflex
- Myelination
- Senescence
- Axon Extension
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ANK2
bosterbio.com/bosterbio-gene-info-cards/ANK2
References
PMID: 1830053 by Otto E., et al. Isolation and characterization of cDNAs encoding human brain ankyrins reveal a family of alternatively spliced genes.
PMID: 8253844 by Chan W., et al. 440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons.