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- Table of Contents
Facts about Arachidonate 12-lipoxygenase, 12R-type.
From the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to create an epoxy-ketone derivative, a vital step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the institution of the skin barrier to water loss.
Human | |
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Gene Name: | ALOX12B |
Uniprot: | O75342 |
Entrez: | 242 |
Belongs to: |
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lipoxygenase family |
12R-LOXEC 1.13.11.-; arachidonate 12-lipoxygenase, 12R type; arachidonate 12-lipoxygenase, 12R-type; EC 1.13.11.33,12R-lipoxygenase; Epidermis-type lipoxygenase 12
Mass (kDA):
80.356 kDA
Human | |
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Location: | 17p13.1 |
Sequence: | 17; NC_000017.11 (8072636..8087716, complement) |
Expressed in B-cells, hair follicles, foreskin keratinocytes and adult skin. Also expressed in psoriatic tissue.
Cytoplasm. Cytoplasm, perinuclear region.
PMID: 9618483 by Boeglin W.E., et al. A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression.
PMID: 9837935 by Sun D., et al. Human 12(R)-lipoxygenase and the mouse ortholog. Molecular cloning, expression, and gene chromosomal assignment.