This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Arachidonate 15-lipoxygenase B.
Also acts on lactic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase action but reacts with (8S)- HPETE to create (8S,15S)-diHPETE.
Human | |
---|---|
Gene Name: | ALOX15B |
Uniprot: | O15296 |
Entrez: | 247 |
Belongs to: |
---|
lipoxygenase family |
15-lipoxygenase 2; 15-LOX-B; arachidonate 15-lipoxygenase 2; arachidonate 15-lipoxygenase B; Arachidonate 15-lipoxygenase type II; arachidonate 15-lipoxygenase, second type; arachidonate 15-lipoxygenase, type B; arachidonate omega(6) lipoxygenase; EC 1.13.11; EC 1.13.11.33,15-LOX-215S-lipoxygenase
Mass (kDA):
75.857 kDA
Human | |
---|---|
Location: | 17p13.1 |
Sequence: | 17; NC_000017.11 (8039040..8049134) |
Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea.
[Isoform A]: Nucleus. Other isoforms are excluded from the nucleus.; Cytoplasm, cytosol. Cell membrane. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Predominantly cytosolic; becomes enriched at membranes upon calcium binding.
PMID: 9177185 by Brash A.R., et al. Discovery of a second 15S-lipoxygenase in humans.
PMID: 11350124 by Krieg P., et al. A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression.