This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Alpha-1A adrenergic receptor.
Atomic ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. .
Human | |
---|---|
Gene Name: | ADRA1A |
Uniprot: | P35348 |
Entrez: | 148 |
Belongs to: |
---|
G-protein coupled receptor 1 family |
a-1A AdrenergicR; ADRA1A; ADRA1Cadrenergic, alpha-1A-, receptor variant 1; ADRA1L1; adrenergic, alpha -1A-, receptor; adrenergic, alpha-1A-, receptor variant 3; adrenergic, alpha-1A-, receptor variant 5; adrenergic, alpha-1A-, receptor variant 8; adrenergic, alpha-1A-, receptor; adrenergic, alpha-1C-, receptor; alpha-1A Adrenergic R; alpha-1A adrenergic receptor; alpha1A AdrenergicR; Alpha-1A adrenoceptor; Alpha-1A adrenoreceptor; ALPHA1AAR; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c; G protein coupled receptor
Mass (kDA):
51.487 kDA
Human | |
---|---|
Location: | 8p21.2 |
Sequence: | 8; NC_000008.11 (26738113..26870994, complement) |
Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.
Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Membrane, caveola. Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
The ADRA1A Marker from Boster Bio is an excellent option for testing the adiponectin receptor. It can be used for a variety of purposes including the identification of certain genes. Its benefits and applications are discussed in this article. This article applies to researchers around the world. Let's discuss the uses of the ADRA1A Marker. This antibody can be used to identify the adiponectin receptor in various species.
The ADRA1A gene is a member of the GPCR family. This gene binds to and interacts with the heterotrimeric G protein containing the Gaq/11 subunit. This G protein is a key activator of phospholipase CE, which promotes the biosynthesis of phosphatidylinositol-4,5-diphosphate. Phosphatidylinositol-4,5-diphosphate, a cellular compound. ADRA1A also functions as a receptor for the metabolic pathway involving the conversion of phosphatedylglycerol to inositol-1,4,5-triphosphate.
In addition, this marker can be used to determine the morphological characteristics of cells. Cells that are double-positive for both POU3F1 and ADRA1A are called uncharacterized. Each donor's layer five cells were characterized morphologically using dISH staining, and the percentage of cells expressing both markers was determined. Cells that were double-positive for both markers were classified as VEN, POU3F1 or uncharacterized. However, the lack of definitive morphological features is likely related to the bisection process during sectioning.
The ADRA1A gene encodes an alpha-adrenergic receptor. This gene is expressed in several tissues, including the heart, liver and brain. Alpha-1A-ARs are members of the G protein-coupled receptor superfamily. They regulate growth and proliferation of a variety of cell types. Previously, they were classified as subtypes that signal through G proteins. However, they differ in their patterns of activation. ADRA1A encodes the alpha-1A-adrenergic receptor.
ADRA1A expression was associated with a poor prognosis in gastric cancer, and the expression of ADRA1A and ADRA1B was associated with a decreased survival rate. In addition to the poor prognostic value of ADRA1, the gene may also play a role in tumour metastasis. Thus, evaluating the ADRA1A gene's expression could help clinicians better identify cancers that have spread to other organs.
The a1A adrenergic receptor subtype is cardioprotective. This study found that the conditional knock-down of the a1A adrenergic receptor, or ADRA1A, results in no baseline deficits. Exercise induces eccentric cardiac hypertrophy in both knock-down and control mice. However, cardiac a1A-adrenergic receptors do not impact adaption to endurance exercise.
The ADRA1A gene is a highly expressed adenovirus-associated protein. It is expressed on the vascular smooth muscle, dermal nerve fibers, blood vessels, and fibroblasts of keloid scars. Best Uses of the ADRA1A marker are limited, but it is an excellent genetic marker for cervical vertigo. In addition, it is expressed on other genes, such as p53.
The PicoKine(tm) Fast ELISA kit offers a fast turnaround time and excellent sensitivity. This solid phase immunoassay combines a biotinylated detection antibody and capture antibody to form a sandwich complex in one step. Next, an Avidin-Biotin-Peroxidase Complex is added as a TMB substrate to form a blue product that is directly proportional to the presence of the target analyte. This PicoKine(tm) Quick ELISA kit has been validated on a wide range of biological samples and offers a guaranteed reaction with the target analyte.
The Boster Quick ELISA kit offers an upgrade from traditional sandwich ELISA. The Boster Quick ELISA requires only 1.5 hours for complete testing and offers supreme sensitivity. The kits are also more sensitive than traditional sandwich ELISAs and can be used in a single laboratory. In addition, Boster Quick ELISA kits are comparable to traditional sandwich ELISAs in terms of quality and accuracy.
PMID: 8396931 by Hirasawa A., et al. Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor.
PMID: 8024574 by Weinberg D.H., et al. Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.